中国组织工程研究Issue(7)：1003-1007,5.DOI:10.3969/j.issn.2095-4344.2015.07.004
人参皂甙Rg1对脊髓神经元细胞增殖的影响
Ginsenoside Rg1 effect on proliferation of spinal neurons
摘要
Abstract
BACKGROUND:Different neuroreceptors medicated by different receptors produce their own biological functions. The root cause of spinal cord injury is the death of neurons and the synaptic dysfunction. Ginsenoside Rg1 may play a protective role in neurons. <br> OBJECTIVE:To verify the nutritional and protective roles of ginsenoside Rg1 in spinal neurons of Sprague-Dawley rats. <br> METHODS:The spinal neurons were isolated from embryonic rats at a gestation age of 16 days, and fol owing cryopreservation and resuscitation, the cel s were divided into three groups:blank group, ginsenoside Rg1 group and positive control group (phenol solution). MTT method was used to detect the activity of mitochondria and ginsenoside Rg1 effects on the neuronal proliferation. <br> RESULTS AND CONCLUSION:Compared with the blank group, the cel absorbance value and cel relative activity were both higher in the ginsenoside Rg1 group, indicating that ginsenoside Rg1 can encourage the growth of neurons. When cel s were intervened by ginsenoside Rg1, cel processes grew faster than those in the blank group, indicating ginsenoside Rg1 can protect the neurons, inhibit neuronal apoptosis, and boost the cel vitality.关键词
组织构建/组织工程/人参皂苷Rg1/脊髓神经元/细胞增殖分类
医药卫生引用本文复制引用
孙建忠,刘欣伟,管华鹏,张鹏,刘琦,杨珺,郭群峰,倪斌..人参皂甙Rg1对脊髓神经元细胞增殖的影响[J].中国组织工程研究,2015,(7):1003-1007,5.基金项目
Funding:the Young Medical Training Program of Baoshan District in Shanghai, No. bswsyq-2014-A03上海市宝山区卫生青年医学人才培养计划资助(bswsyq-2014-A03) （bswsyq-2014-A03）
