中国组织工程研究Issue(7)：1099-1103,5.DOI:10.3969/j.issn.2095-4344.2015.07.021
表观遗传修饰与溃疡性结肠炎
Ulcerative colitis and epigenetic modification
摘要
Abstract
BACKGROUND:Ulcerative colitis is found to have a complicated occurrence and development process, which is involved in the response of susceptibility genes to the variation of intestinal microbial internal environmental and other external environmental factors that is able to both induce the body’s innate immune and specific immune protection and tolerance, and lead to chronic inflammation. <br> OBJECTIVE:To analyze the progress in the studies about ulcerative colitis and epigenetic modifications in recent 10 years and then to discuss the correlation of susceptibility genes of ulcerative colitis, epigenetic modifications and changes to the occurrence and development of ulcerative colitis. <br> METHODS:PubMed and Wanfang databases were searched for relevant articles published between January 2000 and January 2015 using the keywords of“ulcerative colitis, epigenetic, DNA methylation, histone modification, miRNA”. According to the exclusion criteria, 28 articles were included in result analysis. <br> RESULTS AND CONCLUSION:The occurrence of ulcerative colitis is primarily associated with susceptibility genes, internal and external environmental factors which are affected by epigenetic modification. Epigenetic modifications include DNA methylation, histone modifications, genes silencing mediated by miRNA. Studies about pathogenic factors of ulcerative colitis show that epigenetic modifications and environmental factors may act in the body’s innate immunity and specific immunity, and epigenetic modification plays a very important role in the occurrence and development of ulcerative colitis.关键词
组织构建/组织工程/溃疡性结肠炎/表观遗传/DNA甲基化/组蛋白修饰/miRNA/国家自然科学基金分类
医药卫生引用本文复制引用
黄艳,窦传字,刘慧荣,吴璐一,陆嫄,王晓梅,胡鸿毅,吴焕淦..表观遗传修饰与溃疡性结肠炎[J].中国组织工程研究,2015,(7):1099-1103,5.基金项目
国家重点基础研究发展计划(973计划)资助项目(2015CB554500)；国家自然科学基金(81303033)；上海市卫生系统优秀青年人才项目(XYQ2011068)Funding:the National Basic Research Program of China (973 Program), No.2015CB554500 （973计划）
the National Natural Science Foundation of China, No.81303033 （）
the Young Talent Project in the Health System of Shanghai, No. XYQ2011068 （）
