中国组织工程研究Issue(7)：1117-1121,5.DOI:10.3969/j.issn.2095-4344.2015.07.024
内皮细胞分化功能在替米沙坦干预高血压患者过程中的变化
Endothelial cell differentiation function varies during telmisartan intervention for hypertension
摘要
Abstract
BACKGROUND:Studies have shown that in patients with essential hypertension endothelial cel damage is characterized as endothelin release imbalance. Telmisartan can recover the“dipper”-type blood pressure in hypertension patients, and has better antihypertensive effect than losartan and amlodipine, showing a stronger protective role. <br> OBJECTIVE:To investigate the effects of telmisartan on endothelial cel differentiation function and serum adiponectin in hypertension patients. <br> METHODS:Total y 160 patients with essential hypertension were equal y divided into treatment group and control group according to lottery method. The control group was given Hyzaar treatment, while the treatment group received telmisartan treatment, one tablet per day that was taken oral y in the morning. The treatment period was 4 weeks. Clinical efficacy, plasma adiponectin, plasma endothelin and nitric oxide levels were observed in the two groups. Correlation between plasma endothelin, plasma adiponectin and nitric oxide levels in patients with hypertension were analyzed. <br> RESULTS AND CONCLUSION:The effective rate was 92.5%in the treatment group and 75.0%in the control group, and there was a significant difference between the two groups (P<0.05). After treatment, the plasma adiponectin and nitric oxide levels were significantly increased, and the plasma endothelin levels were decreased significantly in the two groups, with significant differences compared to pre-treatment (P<0.05). Compared with the control group, the plasma endothelin level was significantly lower while the nitric oxide level was significantly higher in the treatment group after treatment (both P<0.05). Pearson correlation test analysis showed that the plasma adiponectin levels were negatively correlated to the plasma endothelin levels (P<0.05), but positively correlated to the plasma nitric oxide levels (P<0.05). These findings indicate that telmisartan treatment can improve the prognosis and therapeutic effects on hypertension, and its role may be related to improve endothelial cel differentiation and increase serum adiponectin levels.关键词
组织构建/组织工程/替米沙坦/高血压/内皮细胞/脂联素分类
医药卫生引用本文复制引用
马健,张勇,曹政..内皮细胞分化功能在替米沙坦干预高血压患者过程中的变化[J].中国组织工程研究,2015,(7):1117-1121,5.基金项目
湖北省教育厅课题(Q20112101)，课题名称替米沙坦对内皮细胞分化功能的影响及其机制研究Funding:the Project of Hubei Provincial Education Bureau, No. Q20112101 （Q20112101）
