中国组织工程研究Issue(10)：1533-1538,6.DOI:10.3969/j.issn.2095-4344.2015.10.011
脐带间充质干细胞联合骨髓干细胞移植治疗失代偿期肝硬化：1年随访对照
Umbilical cord mesenchymal stem cells with bone marrow stem cells in the treatment of decompensated cirrhosis：a 1-year follow-up study
摘要
Abstract
BACKGROUND:There are most single-center studies about bone marrow stem cels applied to treat decompensated cirrhosis, but the therapeutic results are not ideal. It is possibly related to aging, physical weakness, poor bone marrow hematopoietic function, less available number of stem cels and feeble ability of regeneration and proliferation in liver cirrhosis patients. Umbilical cord mesenchymal stem cels are characterized of easy to obtain, wide source and weak immunogenicity. Co-transplantation of bone marrow stem cels and umbilical cord mesenchymal stem cels may improve the therapeutic effects on decompensated cirrhosis patients. OBJECTIVE:To investigate the efficacy and safety of co-transplantation of umbilical cord mesenchymal stem cels and bone marrow stem cels on decompensated cirrhosis.METHODS:Thirty-two decompensated cirrhosis patients were randomly divided into two groups: in stem cel group, 13 patients received co-transplantation of umbilical cord mesenchymal stem cels and bone marrow stem cels based on regular medical treatment; in control group, 19 patients only underwent the regular medical treatment. Al the patients were folow-up for 1 year. Alanine aminotransferase, albumin, total bilirubin, prothrombin time, Child-Pugh score and Model for End-Stage Liver Disease score, 1-year survival rate, Quality of Life score and adverse reactions related to stem cel therapy were observed and recorded in the two groups at 4, 12, 52 weeks after treatment. RESULTS AND CONCLUSION:At 4, 12, 52 weeks after treatment, improvements in the liver function, prothrombin time, Child-Pugh score and Model for End-Stage Liver Disease score were found in the two groups, but there was no difference between the two groups (P > 0.05). At 4 weeks after transplantation, the clinical symptoms and Quality of Life score in the stem cel group were significantly improved, which were better than those in the control group (P < 0.05). But at 12 and 52 weeks after treatment, no difference was found between the two groups (P > 0.05). In addition, the 1-year survival rate showed no difference between the two groups, and no severe adverse reactions related to stem cel therapy occurred during the folow-up. Co-transplantation of umbilical cord mesenchymal stem cels and bone marrow stem cels is safe and effective to improve the clinical symptoms of decompensated cirrhosis patients. However, further studies with larger samples are warranted to better clarify the co-transplantation effects.关键词
干细胞/移植/脐带间充质干细胞/骨髓干细胞/失代偿期肝硬化/疗效/安全性/肝功能/凝血酶原时间/Child-Pugh评分/MELD评分/1年生存率Key words
Umbilical Cord/Mesenchymal Stem Cel Transplantation/Myeloid Progenitor Cels/Liver Cirrhosis/Treatment Outcome分类
医药卫生引用本文复制引用
曾芝雨,李东良,方坚,阮梅,夏磊,张志强,张世安..脐带间充质干细胞联合骨髓干细胞移植治疗失代偿期肝硬化：1年随访对照[J].中国组织工程研究,2015,(10):1533-1538,6.基金项目
福建省社会发展重点资助项目(2011Y0043)；南京军区医学科技创新基金资助项目(2007534)Funding：the Key Project of Fujian Province Science and Technology, No.2011Y0043 （2011Y0043）
the Medical Science and Technology Innovation Foundation of Nanjing Military Region, No.2007534 （）
