中国组织工程研究Issue(14)：2267-2272,6.DOI:10.3969/j.issn.2095-4344.2015.14.023
温阳益气法对肿瘤微环境中骨髓间充质干细胞炎性平衡及遗传稳定性的调控
Regulatory effects of warming yang and invigorating qi treatment on the inflammatory balance and genetic stability of bone marrow mesenchymal stem cells under tumor microenvironment
摘要
Abstract
BACKGROUND:How to further definite and prevent the genetic instability of bone marrow mesenchymal stem cel s in tumor microenvironment has increasingly become a key problem for its clinic application. Meanwhile, increasing studies focus on the reciprocal causation relationship between uncontrol ed inflammation and tumors. OBJECTIVE:To analyze the changes of inflammation-related signaling pathways and genetic stability in bone marrow mesenchymal stem cel s under the tumor microenvironment, and meanwhile, to investigate the influence and mechanism of“warming yang and benefiting qi”method on inflammatory signaling pathways and the genetic stability of bone marrow mesenchymal stem cel s in tumor microenvironment, based on the guidance of the traditional Chinese Medicine theories“warming yang and tonifying kidney, benefiting qi and raising yang, strengthening healthy and discarding evil to eliminate pathogens”. METHODS:A computer-based online search of PubMed, CNKI and VIP was performed for relevant articles with the keywords of“bone marrow mesenchymal stem cel s, inflammatory balance, replenishing qi, warming yang, strengthening shen, elevate yang, tumor, cancer, yang can transform qi, yin shaping up body, genetic stability”in English and Chinese, respectively. Screened literatures were evaluated strictly according to the inclusion and exclusion criteria, and final y 42 articles were included in result analysis. RESULTS AND CONCLUSION:Under physical and chemical induction or tumor microenvironment, bone marrow mesenchymal stem cel s can promote tumor proliferation, invasion and metastasis. In addition, bone marrow mesenchymal stem cel s can be induced to differentiate into malignant cel s or tumor associating fibroblasts, fol owed by genetic instability, in tumor microenvironment. Inflammatory microenvironment plays an important role in regulating inflammation-related signals and genetic stability of bone marrow mesenchymal stem cel s. Chinese traditional medicines functioning as“warming yang and replenishing qi”can restore the genetic stability of bone marrow mesenchymal stem cel s in tumor or chemical microenvironment, based on the guidance of the traditional Chinese Medicine theories of“warming yang and tonifying kidney, benefiting qi and raising yang, strengthening healthy and discarding evil to eliminate pathogens”.关键词
干细胞/骨髓干细胞/炎性平衡/炎骨髓间充质干细胞/温阳益气/遗传稳定性/国家自然科学基金Key words
Bone Marrow/Mesenchymal Stem Cells/Tumor Microenvironment/Drugs, Chinese Herbal分类
医药卫生引用本文复制引用
高卓越,周妮娜,刘永琦,何建新,伍志伟,骆亚莉,苏韫,张利英,张齐,武有明..温阳益气法对肿瘤微环境中骨髓间充质干细胞炎性平衡及遗传稳定性的调控[J].中国组织工程研究,2015,(14):2267-2272,6.基金项目
甘肃省杰出青年基金项目“基于调控Wnt等信号通路研究当归预防肺癌微环境中MSCs恶性转化的作用(1308RJDA008)”；国家自然科学基金项目“从炎性信号通路失衡研究肺癌微环境中MSCs恶性转化的分子机制及黄芪调控作用研究(81360588)”、及“黄芪对重离子辐射诱发肺癌相关MSCs旁效应及基因组不稳定的防护机制研究(81473457)”@@@@the Outstanding Youth Foundation of Gansu Province, No.1308RJDA008 （1308RJDA008）
the National Natural Science Foundation of China, No.81360588,81473457 （）
