中国组织工程研究Issue(23)：3692-3697,6.DOI:10.3969/j.issn.2095-4344.2015.23.015
自体骨髓干细胞移植治疗血栓闭塞性脉管炎：5年随访
Autologous bone marrow stem cell transplantation for thromboangiitis obliterans：5-year follow-up
摘要
Abstract
BACKGROUND:The assessment for long-term efficacy of chronic ischemic disease is more important than the short-term efficacy assessment, which associates with patient’s long-term quality of life and long-term survival rate. OBJECTIVE:To observe the 5-year folow-up outcomes of autologous bone marrow stem cel transplantation for the treatment of thromboangitis obliterans. METHODS:This study enroled 43 patients of thromboangitis obliterans who underwent autologous bone marrow stem cel transplantation from August 2007 to January 2010 in the Department of Thyroid Vascular Surgery, the First Affiliated Hospital of Xinjiang Medical University. At 1, 2, 3, 4 and 5 years after transplantation, pain, cold sensation, and intermittent claudication distance were folowed up by telephone; changes in limb ulcers were observed. At 1 year after transplantation, venous oxygen partial pressure and oxygen saturation of limbs were reviewed. RESULTS AND CONCLUSION:A total of 38 thromboangitis obliterans patients with complete folow-up data were included in the final analysis. Compared to the preoperation, pain, cold sensation, and intermittent claudication significantly improved. The difference was statisticaly significant (Z values:-4.277,-5.086,-3.574, P < 0.001). Compared with 1-5 years after operation, pain and cold sensation had no statisticaly difference (P >0.05). Intermittent claudication distance had increased. Differences in terms of intermittent claudication distance was statisticaly significant (Z=43.898,P < 0.001). Significant differences in venous oxygen partial pressure and oxygen saturation were detected between preoperation and 1-year posttransplantation (tvalues: 36.790, 43.964,P values: 0.040, 0.037). Above results suggest that autologous bone marrow stem cel transplantation for thromboangitis obliterans obtained stable long-term outcomes.关键词
干细胞/移植/血栓闭塞性脉管炎/自体骨髓干细胞/疼痛/冷感/间歇性跛行/长期疗效/新疆维吾尔自治区自然科学基金Key words
Myeloid Progenitor Cells/Transplantation, Autologous/Thromboangiitis, Obliterans/Treatment Outcome分类
医药卫生引用本文复制引用
白超,郭晨明,罗军..自体骨髓干细胞移植治疗血栓闭塞性脉管炎：5年随访[J].中国组织工程研究,2015,(23):3692-3697,6.基金项目
the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No.2010211A48新疆维吾尔自治区自然科学基金资助项目(2010211A48) （2010211A48）
