中国组织工程研究Issue(23)：3744-3749,6.DOI:10.3969/j.issn.2095-4344.2015.23.023
磁场对骨髓间充质干细胞分化的影响
Effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cells
摘要
Abstract
BACKGROUND:Bone marrow mesenchymal stem cels have the ability to differentiate into a variety of non-hematopoietic tissue cels. Effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cels have attracted a lot of attention in recent years. OBJECTIVE:To summarize the effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cels towards osteoblasts, chondrocytes, adipocytes, nerve cels and cardiomyocytes, which provide references for the research and application of tissue engineering seed cels as wel as the clinical applications of magnetic fields. METHODS:The first author performed a data retrieval of PubMed and CNKI databases from 2000 to 2015 to search the articles addressing the effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cels, and reviewed the literatures systematicaly. Finaly, 40 articles were chosen for further analysis. RESULTS AND CONCLUSION:Magnetic fields can promote the differentiation of bone marrow mesenchymal stem cels towards osteoblasts, chondrocytes, nerve cels and cardiomyocytes, and inhibit the differentiation of bone marrow mesenchymal stem cels towards adipocytes. There are optimal frequency and intensity in the induction of magnetic fields on the differentiation of bone marrow mesenchymal stem cels. In general, low-intensity and low-frequency magnetic fields have more obvious effects on bone marrow mesenchymal stem cels. The facilitation of magnetic fields on the differentiation of bone marrow mesenchymal stem cels is also a time-dependent behavior.关键词
干细胞/骨髓干细胞/磁场/骨髓间充质干细胞/分化/成骨细胞/软骨细胞/脂肪细胞/神经细胞/心肌细胞/国家自然科学基金Key words
Bone Marrow/Mesenchymal Stem Cells/Electromagnetic Fields/Cell Differentiation分类
医药卫生引用本文复制引用
张静,詹琪,黄艳..磁场对骨髓间充质干细胞分化的影响[J].中国组织工程研究,2015,(23):3744-3749,6.基金项目
the National Natural Science Foundation of China, No.11302020国家自然科学基金项目(11302020) （11302020）
