中国组织工程研究2015，Vol.19Issue(19)：3083-3088,6.DOI:10.3969/j.issn.2095-4344.2015.19.022
骨髓间充质干细胞修复软骨缺损的应用前景
Bone marrow mesenchymal stem cells for repair of cartilage defects
摘要
Abstract
BACKGROUND:Bone marrow mesenchymal stem cels are a kind of non-hematopoietic adult stem cels, mainly distributing in the bone marrow, with strong proliferation and differentiation potential, which has a promising clinical prospect. OBJECTIVE:To review the latest progress in growth factors and biological scaffolds to promote chondrogenic differentiation of bone marrow mesenchymal stem cels. METHODS:PubMed and CNKI databases were searched by the first author using key words of "cartilage defects, tissue engineering, biological scaffolds, bone marrow mesenchymal stem cels, cytokines" in English and in Chinese, respectively, to retrieve relevant articles published from 1990 to 2014. Literatures addressing the chondrogenic differentiation of bone marrow mesenchymal stem cels were included, and 51 articles were chosen for further analysis eventualy. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cels have the potential to differentiate into chondrocytes, which can be induced by many cytokines. Various biological scaffolds act as a carrier for chondrogenic differentiation of bone marrow mesenchymal stem cels. But there are stil lots of problems to be solved and in-depth explored clinicaly.关键词
干细胞/骨髓干细胞/软骨缺损/组织工程/生物支架/骨髓间充质干细胞/细胞因子分类
医药卫生引用本文复制引用
鲁先闯,张志峰,黄健..骨髓间充质干细胞修复软骨缺损的应用前景[J].中国组织工程研究,2015,19(19):3083-3088,6.基金项目
the Scientific Milions Engineering of Inner Mongolia Medical University, No. YKD2012KJBW003 内蒙古医科大学科技百万工程(YKD2012KJBW003) （YKD2012KJBW003）
