中国实用神经疾病杂志Issue(12)：46-47,48,3.
齐拉西酮与利培酮治疗青年女性精神分裂症的疗效及对代谢的影响
Effective comparison of ziprasidone and risperidone in young female patients with schizophrenia and the influ-ence on metabolism
摘要
Abstract
Objective To compare the effectiveness of ziprasidone and risperidone in young female patients with schizo-phrenia and the influence on metabolism.Methods 116 young female patients with schizophrenia were randomly divided into zi-prasidone group and risperidone group.The two groups received ziprasidone and risperidone treatment respectively.The course of treatment was 8 weeks.Clinical effectiveness ,adverse reactions and the influence on metabolism were compared between the two groups.Results There were no significant difference of PANSS scores on 8 weeks after treatment between two groups (P >0.05);The occurrence of extrapyramidal symptom ,weight gain and lactation and menstruation abnormality in risperidone group were much higher than those in ziprasidone group (P<0.05);No difference of BMI and prolactin were found before and after treatment in ziprasidone group (P>0.05);Compared with ziprasidone group ,BMI and prolactin greatly increased in ris-peridone group (P< 0.05).Conclusion Ziprasidone and risperidone have equivalent effectiveness for young female patients with schizophrenia ,while ziprasidone is more favorable for young female patients for less influence on metabolism.关键词
精神分裂症/女性/齐拉西酮/利培酮/代谢Key words
Schizophrenial/Female/Ziprasidone/Risperidone/Metabolism分类
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李杰..齐拉西酮与利培酮治疗青年女性精神分裂症的疗效及对代谢的影响[J].中国实用神经疾病杂志,2014,(12):46-47,48,3.
