中国实用神经疾病杂志Issue(12)：49-50,2.
齐拉西酮治疗老年期痴呆精神行为异常的疗效及对糖脂代谢的影响
Effect of ziprasidone on senile dementia complicated with psychiatric and behavioral symptoms and the influ-ence on glucose and lipid metabolism
摘要
Abstract
Objective To explore the effect of ziprasidone on senile dementia complicated with psychiatric and behavioral symptoms and the influence on glucose and lipid metabolism .Methods 118 cases of senile dementia complicated with psychiat-ric and behavioral symptoms were randomly divided into risperidone group and ziprasidone group .The course of treatment was 3 months .BEHAVE-AD and TESS scales were used to evaluate the effectiveness and the rate of side effect .The indexes of glu-cose and lipid metabolism were compared between two groups .Results After treatment ,BEHAVE-AD scores greatly de-creased in two groups (P< 0 .05);There were no significant difference of BEHAVE-AD between two groups (P> 0 .05);Weight gain ,lactation and menstruation abnormality rates in risperidone group were much higher than those in ziprasidone group (P<0 .05);Compared with ziprasidone group ,fasting blood glucose ,TC ,LDL-C and insulin of risperidone group great-ly increased (P<0 .05) .Conclusion ziprasidone and risperidone have equivalent clinical efficacy in treatment of senile dementia complicated with psychiatric and behavioral symptoms ,while ziprasidone has less side effects and influence on glucose and lipid metabolism .关键词
老年痴呆/精神行为异常/齐拉西酮/利培酮Key words
Senile dementia/Psychiatric and behavioral disorders/Ziprasidone/Risperidone分类
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陈斌..齐拉西酮治疗老年期痴呆精神行为异常的疗效及对糖脂代谢的影响[J].中国实用神经疾病杂志,2014,(12):49-50,2.
