中国实用神经疾病杂志Issue(14)：1-3,3.
重症手足口病患儿血清NSE及S100β蛋白变化及临床意义
The alteration of the NSE and S100β-protein in childhood Severe hand,foot and mouth disease and their clini-cal significance
摘要
Abstract
Objective To explore the serum levels of the NSE and S100β-protein in childhood Severe hand ,foot and mouth disease before and after the therapy and their clinical significance.Methods 110 patients of children with severe hand ,foot and mouth disease were enrolled in this study ,and randomly divided into heavy group(n= 61) and severe group(n= 49) ,mild HFMD(n=40) ,control group (n=30) ,EIA was used to detect the serum levels of NSE.Results The elevated serum levels of NSE and S100β-protein were found in SHFMD group ,compared with those of control group and normal cases group ;the lower levels of NSE and S100β-protein were found in heavy group after the therapy ,and there were no changes in severe group after the therapy.Conclusion There were some degrees of injury of the neurons and the glial cells in severe hand ,foot and mouth disease;the levels of serum NSE and S100β-protein were in line with severity of the HMFD and can early reflect the de-gree of brain damage ,as well as the prognosis of HFMD. They have small damage to children and are worth of clinical promo-tion.关键词
重症手足口病/神经元特异性烯醇化酶/S100β蛋白Key words
Severe hand foot and mouth disease/NSE/S100β-protein分类
医药卫生引用本文复制引用
宋春兰,成怡冰,金志鹏,吴值荣,陈丹,顾雪..重症手足口病患儿血清NSE及S100β蛋白变化及临床意义[J].中国实用神经疾病杂志,2014,(14):1-3,3.基金项目
郑州市科技局科研项目 （）
