摘要
Abstract
Objective To explore the incidence rate of epilepsy secondary to Alzheimer ,s disease (AD)、its pathogenesis、clinical treatment and its effect on AD. Methods the data of 120 patients with AD from 2000-2012 were retrospectively ana-lyzed ,the incidence rate of Epilepsy secondary to AD was analyzed. 19 AD patients complicated with Epilepsy were classified to the observation group ,101 AD patients without Epilepsy to the control group. And then the clinical treatment and accessory examinations of 19 AD patients complicated with Epilepsy and the effect of Epilepsy on AD were analyzed. Results Among the 120 AD patients ,19 cases were complicated with Epilepsy (15.8% ) ,Among which ,7 cases occurred in early stage ,3 cases in middle ,9 cases in late ;according to the seizure types of Epilepsy ,they included :8 cases of generalized tonic-clonic seizure ,13 cases of complex partial seizures ,2 cases of simple partial seizure. 2 cases of the 19 patients had status epilepticus ;Mean age of AD patients with Epilepsy was less than that of AD without Epilepsy (P<0.05) ,mean survival time of AD patients with Epi-lepsy was shorter than that of those without Epilepsy (P<0.05) ;Brain atrophy was significantly obvious in AD with Epilepsy group ;The antiepileptic drug was not very effective in controlling the Epileptic seizure in patients with AD ,The frequency of Epileptic seizures increased as the symptoms of AD exacerbated. Conclusion The incidence rate of Epilepsy in AD is 15.8%.Epilepsy may occur at any time in AD ,mean age of onset of Epilepsy in AD is small ,mean survival time is short. Epilepsy can worsen AD symptoms and shorten the survival time of AD. The pathogenesis of Epilepsy in AD is associated with loss of neu-rons ,temporal lobe and hippocampal sclerosis. The antiepileptic drug is not very effective in controlling the Epileptic seizure in patients w ith AD.关键词
阿尔茨海默病/癫痫Key words
Alzheimer’s disease/Epilepsy分类
医药卫生
