中国实用神经疾病杂志Issue(20)：16-17,2.
自体骨髓间质干细胞移植治疗多系统萎缩34例分析
Analysis of autologous marrow mesenchymal stem cell transplantation on treating 34 patients with multiple system atrophy
屈新辉 1项正兵 1周超 1高幼奇 1张昆南 1吴晓牧1
作者信息
- 1. 江西省人民医院神经内科 江西省神经病学研究所 南昌 330006
- 折叠
摘要
Abstract
Objective To investigate the clinical effect and safety of autologous marrow mesenchymal stem cells (MSCs) transplantation on treating patients with multiple system atrophy. Methods 34 patients with multiple system atrophy (inclu-ding 26 patients with olive pons cerebellum atrophy and 8 patients with striatum nigra degeneration ) from January 2010 to July 2012 in our department were selected. After all patients were mobilized with granulocyte colony-stimulating factor (G-CSF) for two days ,their MSCs were obtained and isolated from own bone marrow ,and then MSCs with number of (5.0~10.0) × 107 were transplanted via subarachnoid space for each patient once per week for 2 weeks. The International Cooperative Ataxia Rating Scale(ICARS) ,Unified Multiple System Atrophy Rating Scale (UMSARS) and Modified Barthel Index (MBI) were used to evaluate the clincal effect and adverse reactions. Results Compared with before transplantation ,the ICARS and UM-SARS were significant decreased and the MBI were significant increased at 1st and 3rd month after treatment (all P<0.05).But the ICARS ,UMSARS and MBI had no significant difference at 12th month after treatment (P>0.05). Among these pa-tients ,7 cases of low grade fever and 4 cases of intracranial hypotension headache were observed. All symptoms were complete restored after symptomatic treatment.Conclusion Autologous MSCs transplantation has mild adverse effects and can amelio-rate clinical symptoms ,as well as improve life quality of patients with multiple system atrophy in the short term ,but not in the long term.关键词
自体骨髓间质干细胞/移植/多系统萎缩Key words
Autologous bome marrow mesenchymal stem cell/Transplantation/Multiple system atrophy分类
医药卫生引用本文复制引用
屈新辉,项正兵,周超,高幼奇,张昆南,吴晓牧..自体骨髓间质干细胞移植治疗多系统萎缩34例分析[J].中国实用神经疾病杂志,2014,(20):16-17,2.
