中国实用神经疾病杂志Issue(23)：17-19,3.
LRRK2活化RhoGTPases信号通路在小胶质细胞吞噬α-突触核蛋白中的作用机制
The functions and mechanisms of Rho GTPases signaling pathway activation induced by LRRK 2 in microglial phagocytosis of α-synuclein
摘要
Abstract
Objective To investigate the mechanism of microglial phagocytosis of α‐synuclein.Methods BV‐2 cells activa‐tion model induced by α‐synuclein oligomers was established. Immunofluorescence stain was performed to detect α‐synuclein‐positive inclusions in BV‐2 cells. Western blot was performed to detect LRRK2 expression in BV‐2 cells. Pull down was per‐formed to detect Rho GTPases signaling pathway activation in BV‐2 cells.Results Compared with the control group ,α‐synucle‐in‐positive inclusions ,LRRK2 expression and Rho GTPases signaling pathway activity in BV‐2 cells significantly increased in theα‐synuclein group.Conclusion The Rho GTPases signaling pathway activation induced by LRRK2 associate closely with mi‐croglial phagocytosis of α‐synuclein.关键词
LRRK2/Rho GTPases信号通路/小胶质细胞/α-突触核蛋白Key words
LRRK2/Rho GTPases signaling pathway/Microglia/α-synuclein分类
医药卫生引用本文复制引用
丁雪冰,王雪晶,马明明,滕军放..LRRK2活化RhoGTPases信号通路在小胶质细胞吞噬α-突触核蛋白中的作用机制[J].中国实用神经疾病杂志,2014,(23):17-19,3.基金项目
国家自然科学基金项目 （）
