中国实用神经疾病杂志Issue(23)：75-77,3.
尿激酶静脉溶栓治疗急性脑梗死有效治疗时间窗分析
Clinical study on valid therapeutic time window of acute cerebral infarction by intravenous thrombolysis with urokinase
高宏章 1陈湛愔 2何国林 2陈逢俭 2林海峰 2陈荣平 1陆治中1
作者信息
- 1. 广东遂溪县人民医院神经内科 遂溪 524300
- 2. 广东湛江市湛江中心人民医院神经内科 湛江 524030
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of intravenous thrombolysis with urokinase on patients with acute cerebral infarction (ACI) .Methods The open clinical trial was conducted on 358 patients with acute cerebral infrac‐tion attacked within 12 hours .Patients enrolled were randomly divided into group of thrombolytic therapy (178 cases ,treated by intravenous thrombolysis with urokinase) and control group (180 cases) .For the group of thrombolytic therapy ,150 mil‐lion U intravenous thrombolysis with urokinase was intravenous injected in addition to routine treatment .Among them ,123 ca‐ses used intravenous thrombolysis with urokinase in ultra‐early stage(thrombolysis therapy within 6 hours) and 55 cases used thrombolysis in the period of 6—12 hours after the onset .The efficacy of thrombolysis and safety of hemorrhagic transformation were evaluated .Results The overall improvement rate of treatment group with intravenous thrombolysis was 89 .89% (114/210) ,fatality rate was 3 .8% (12/178) ,cerebral hemorrhagic transformation rate was 5 .7% (12/210) ,cerebral hemorrhagic mortality rate was 2 .9% (6/210);The Overall improvement rate of control group was 48% (108/225) ,fatality rate was 9 .3%(21/225) ,cerabral hemorrhagic transformation rate was 0 .9% (2/225) ,cerebral hemorrhagic mortality rate was 0 .There were no statistical differences on NIHSS score and prognostic outcome between ultra‐early thrombolysis therapy and delayed thrombolytic therapy .Conclusion For hyperacute ischemic stroke patients ,intravenous urokinase thrombolysis shows obvious effect on ultra early stage .AS for post therapeutic window (<12 h)of cerebra1 infarction ,it is safe and effective to use intra‐venous thrombolysis with urokinase after attack .Although the risk of hemorrhagic transformation increased ,clinical end point w as no t .关键词
脑梗死/静脉溶栓/尿激酶Key words
Cerebral infarction/Intravenous thrombolysis/U rokinase分类
医药卫生引用本文复制引用
高宏章,陈湛愔,何国林,陈逢俭,林海峰,陈荣平,陆治中..尿激酶静脉溶栓治疗急性脑梗死有效治疗时间窗分析[J].中国实用神经疾病杂志,2014,(23):75-77,3.
