摘要
Abstract
Objective To investigate clinical effects of early enteral nutrition combined with proton pump inhibitors in treatment of stress ulcer in stroke patients and its influence on prognosis .Methods 100 patients with stroke were randomly di‐vided into groups A (n=48 only treated with proton pump inhibitors) and group B (n=52 treated with proton pump inhibitors plus early enteral nutrition) .The incidence rate of stress ulcer ,gastric acid levels and prognosis in two groups were colected and analyzed statistically .Results Rate of gastric occult blood , fecal occult blood and stress ulcer in the mild of group A was 6 . 90% ,3 .45% and 10 .34% ,while 3 .15% ,0 and 3 .15% in group B ,so the difference were small ,no statistically significant (P>0 .05) .Rate of gastric occult blood ,fecal occult blood rate and stress ulcer rates in the severe were 42 .11% ,21 .05% , 63 .16% ,while 15 .00% ,5 .00% and 20 .00% in group B ,so group A was obviously higher than group B ,statistically signifi‐cant(P<0 .05) .The time of pH of group A was less than 4 during 24h and during the night were (3 .10 ± 0 .33)% and (2 .12 ± 0 .58)% ,group B being (2 .09 ± 0 .42)% and (1 .18 ± 0 .54)% ,which were significantly higher than group B and the differ‐ence was statistically significant .39 .58% in cure rate of group A was distinctly lower than 50 .00% of group B ,while 12 .50%in mortality rate of group A was distinctly higher than 3 .85% of group B ,the differences had statistical significance(P<0 . 05) .Conclusion Proton pump inhibitor combined with early enteral nutrition can effectively reduce the incidence of stress ul‐cer ,increase gastric pH improve progrosis ,which is a good treatment .关键词
脑卒中/质子泵抑制剂/早期肠内营养/应激性溃疡Key words
Stroke/Proton pump inhibitors/Early enteral nutrition/Stress ulcer分类
医药卫生
