中国实用神经疾病杂志Issue(11)：22-23,2.
结核性脑膜炎和病毒性脑炎患者的血脑屏障破坏与脑脊液蛋白质指数变化
Study on the disruption of blood brain barrier and variation of cerebrospinal fluid protein index in patients with tuberculous meningitis or viral encephalitis
张利娟 1刘信东 1赵丽君 1杨乐 1段海宇1
作者信息
- 1. 核工业416医院神经内科 成都 610000
- 折叠
摘要
Abstract
Objective To investigate the relationship between the disruption of blood brain barrier and variation of cerebro‐spinal fluid protein index and the immune status of central nervous system in patients with tuberculous meningitis or viral en‐cephalitis. Methods 31 patients with tuberculous meningitis were selected as the tuberculosis group ,27 patients with viral en‐cephalitis were selected as virus group ,and while another 22 patients without any central nervous system infection were selected as the control group ,with no significant differences among the three groups in both sex and age. Immune turbidimetric method was used to detect the content of albumin ,IgA ,IgM and IgG in the serum and cerebrospinal fluid of three groups. The varia‐tion of indexes of albumin ,IgA ,IgM and IgG in the cerebrospinal fluid were calculated and analyzed.Results The level of al‐bumin in the cerebrospinal fluid and cerebrospinal fluid albumin index in the tuberculosis group were higher than those in the control group (P<0.05). The disruption of blood brain barrier and the indexes of IgA ,IgG and IgM in both the tuberculosis group and the virus group were higher than those in the control group (P<0.05).Conclusion The disruption of blood brain barrier and the central immune reaction in the tuberculosis group is more serious than that in the viral group.关键词
结核性脑膜炎/病毒性脑炎/血脑屏障/脑脊液白蛋白指数Key words
Tuberculous meningitis/Viral encephalitis/Blood brain barrier/Cerebrospinal fluid albumin index分类
医药卫生引用本文复制引用
张利娟,刘信东,赵丽君,杨乐,段海宇..结核性脑膜炎和病毒性脑炎患者的血脑屏障破坏与脑脊液蛋白质指数变化[J].中国实用神经疾病杂志,2015,(11):22-23,2.
