癌变·畸变·突变Issue(4)：288-291,297,5.DOI:10.3969/j.issn.1004-616x.2014.04.011
MMP-2和E-cadherin蛋白在食管黏膜病变中的表达
Expressions of MMP-2 and E-cadherin in esophageal mucosal lesion
刘江惠 1王晓旭 1左连富1
作者信息
- 1. 河北医科大学第四医院肿瘤研究所，河北石家庄 050011
- 折叠
摘要
Abstract
To explore the relationship between the protein expressions of MMP-2 and E-cadherin and the development and metastasis of esophageal carcinoma. METHODS:The expressions of E-cadherin protein and MMP-2 protein were examined by immunohistochemistry (IHC) in 45 cases of esophageal carcinoma,21 cases of atypical hyperplasia and 24 cases of normal esophageal mucosa tissues. RESULTS:The positve rates of MMP-2 protein were 40.00%(18/45) in esophageal carcinoma,38.1%(8/21) in esophageal atypical hyperplasia and 4.17%(1/24) in normal tissues. There were significant differences among three groups (P<0.05). Additionally,the expression of MMP-2 protein had a correlation with lymph node metastasis (P<0.05). The positve rate of MMP-2 protein in esophageal cancer tissues with lymph node metastasis was 55.56% (15/27) , significantly higher than that in esophageal cancer tissues without lymph node metastasis (16.67%,3/18). The positve rate of MMP-2 protein in esophageal cancer tissues with fibrous membrane infiltration was higher than that in esophageal cancer tissues without fibrous membrane infiltration(48.57%,17/35;10.00%,1/10). The positive rate of E-cadherin protein in normal tissues (100%) was much higher than that in esophageal carcinoma (28.89%) and esophageal atypical hyperplasia (71.43%). According to these results,the expression of E-cadherin protein had a negative correlation with the expression of MMP-2 protein 2( =4.615,r=-0.793,P<0.05). CONCLUSION:There were significant relationships between the high expression of MMP-2 protein and low expression of E-cadherin protein with the development and metastasis of esophageal carcinoma.Furthermore,the expression of E-cadherin protein had a negative correlation with the expression of MMP-2 protein in the invasion and metastasis of esophageal carcinoma.关键词
食管黏膜病变/MMP-2/E-cadherin/免疫组化Key words
esophageal mucosal lesion/MMP-2/E-cadherin/immunohistochemistry引用本文复制引用
刘江惠,王晓旭,左连富..MMP-2和E-cadherin蛋白在食管黏膜病变中的表达[J].癌变·畸变·突变,2014,(4):288-291,297,5.
