癌变·畸变·突变Issue(1)：49-53,58,6.DOI:10.3969/j.issn.1004-616x.2014.01.011
低氧诱导因子-1α与卵巢上皮癌临床病理关系的Meta分析
Relationship between hypoxia inducible factor -1αand clinicopathology of epithelial ovarian cancer:Meta analysis
孙彩霞 1景绍武 2王军 2许英杰3
作者信息
- 1. 河北省唐山市丰南区中医院妇产科，河北唐山063300
- 2. 河北医科大学第四医院放疗科，河北石家庄050011
- 3. 河北大学附属医院眼科，河北 保定 071000
- 折叠
摘要
Abstract
OBJECTIVE:To explore the expression of hypoxia inducible factor-1α (HIF-1α) in epithelial ovarian cancer and its relationship with clinical pathology,in order to understand the effect of HIF-1α in malignant biological behavior of ovarian epithelial carcinoma clear.METHODS:Original foreign literatures on the correlation between HIF-1α and epithelial ovarian cancer were selected from Cochrane Library,EMbase database,Pubmed,and Chinese original literatures were from CNKI,CBM. All analyses were performed by software STATA 11.0. Relationships between HIF-1α expression and age,pathological type,histological grade,lymph node metastasis,clinical stage were analyzed using pooled odds ratio (OR) with 95% confidence interval (CI).RESULTS:A total of 6 papers including 257 cases of epithelial ovarian cancer were analyzed. Compared with that in normal tissue,total positive rate of HIF-1αin epithelial ovarian cancer was 72.4%,which was increased significantly (OR=0.036,95%CI:0.010-0.135,P=0.000); HIF-1α was significantly correlated with lymph node metastasis and clinical stage(OR=0.080,95%CI:0.029-0.220,P=0.000;OR=0.258, 95%CI:0.136-0.490,P=0.000). Patients with positive expression of HIF-1α were prone to lymph node metastasis and advanced clinical stage. HIF-1α had no significant relation with age,pathological type and pathological grading (P>0.05). CONCLUSION:The expression of HIF-1α protein increased the risk of epithelial ovarian cancer. HIF-1α could be used as indicator of lymph node metastasis and clinical stage.关键词
低氧诱导因子-1α/卵巢肿瘤/低氧/免疫组化Key words
hypoxia inducible factor-1α/ovarian carcinoma/hypoxia/immunohistochemistry分类
医药卫生引用本文复制引用
孙彩霞,景绍武,王军,许英杰..低氧诱导因子-1α与卵巢上皮癌临床病理关系的Meta分析[J].癌变·畸变·突变,2015,(1):49-53,58,6.
