安徽医科大学学报Issue(5)：625-628,4.
TLR4和NF-资B在肝内胆管结石相关的肝内胆管细胞癌中的表达及临床意义
Expression and clinical significance of NF-κB and TLR4 in intrahepatic lithiasis associated with intrahepatic cholangiocarcinoma
摘要
Abstract
Objective To investigate the expressions and clinical significance of NF-κB and TLR4 in intrahepatic lithiasis associated with intrahepatic cholangiocarcinoma. Methods Collect bile duct histopathologic wax blocks of liver tissues specimen of hepatectomy which were selected in department of pathology of the first affiliated hospital of Anhui medical university in recent 10 years, including 40 cases of intrahepatic bile duct calculi of intrahepatic bile duct carcinoma tissue,40 cases of intrahepatic biliary calculi by bile duct tissues and 30 cases of normal bile duct tissues( normal bile duct tissues adjacent to liver hemangioma or liver trauma after resection of liver tissue of normal bile duct tissues) . Immune histochemical method ( PV) was tested in organizations in NF-κB and the expression of TLR4 and results were analyzed. Results The amount of NF-κB and TLR4 expression in intrahepatic biliary calcu-li of intrahepatic bile duct carcinoma tissue was significantly higher than that in the intrahepatic bile duct stones near bile duct tissues and normal bile duct tissue ( P<0.05 ) . The expression of TLR4 and NF-κB in intrahepatic biliary calculi of intrahepatic bile duct carcinoma was correlative and presents positive correlation(r=0.709). The comparison between groups of patients’age, sex, tumor differentiation, tumor invasion and lymph node metastasis that related the expression of TLR4 and NF-κB showed that there was no statistically significant difference ( P >0.05 ) . Conclusion The abnormal expression of TLR4 and NF-κB is closely associated with the gradual progress of intrahepatic bile duct stones complicated with intrahepatic bile duct carcinoma, and both are positively correla-ted.关键词
胆管细胞癌/TLR4/NF-κB/肝内胆管结石Key words
cholangiocarcinoma/TLR4/NF-κB/intrahepatic分类
医药卫生引用本文复制引用
陈佳,余宏铸,王正林,张晓亮..TLR4和NF-资B在肝内胆管结石相关的肝内胆管细胞癌中的表达及临床意义[J].安徽医科大学学报,2014,(5):625-628,4.基金项目
2013年安徽省年度重点科研项目(编号:1301043034) （编号:1301043034）
