安徽医科大学学报Issue(6)：768-771,772,5.
白芍总苷对糖尿病大鼠肾组织中内质网应激的影响
Effect of total glucosides of paeony on endoplasmic reticulum stress in the kidney from diabetic rats
摘要
Abstract
Objective To study the effect of total glucosides of paeony ( TGP) on endoplasmic reticulum stress in the kidney from experimental diabetic rats. Methods Rats were randomly divided into three groups:control group, model group and TGP treated groups. Diabetes rat model was induced with streptozotocin. In TGP group, TGP 50, 100,200 mg/(kg·d) were orally administered once a day for 8 weeks. The expressions of GRP78,p-PERK and p-eIF2α were determined by immunostaining in the kidney. Results The urinary albumin excretion rate( UAER) in model group was significantly higher than that in TGP treatment group. Analysis of the immunostaining showed the expression of GRP78,p-PERK and p-eIF2α was significantly increased compared with control rats in the kidney. TGP treatment with 50,100 and 200 mg/(kg·d) could markedly reduce GRP78 and p-PERK expression in the tu-bulointerstitium,p-eIF2αexpression in the glomeruli and tubulointerstitium. Conclusion The TGP protection of re-nal tissue in diabetic rats may be associated with inhibition of endoplasmic reticulum stress.关键词
糖尿病肾病/内质网应激/白芍总苷Key words
diabetic nephropathy/endoplasmic reticulum stress/total glucosides of paeony分类
医药卫生引用本文复制引用
武晓旭,章超群,许坤,徐兴欣,吴永贵..白芍总苷对糖尿病大鼠肾组织中内质网应激的影响[J].安徽医科大学学报,2014,(6):768-771,772,5.基金项目
国家自然科学基金(编号:81270813、81374034) （编号:81270813、81374034）
教育部高等学校博士学科点专项科研基金(编号:20093420110003) （编号:20093420110003）
