安徽医科大学学报Issue(6)：804-807,4.
中青年甲亢患者血清PINP、β-CTx与骨密度关系分析
Relationship analysis between serum PINP and β-CTx and bone metabolism in adult patients with hyperthyroidism
摘要
Abstract
Objective To explore the changes in serum type I procollagen N-terminal propeptide ( PINP) and c-terminal telopeptide region of collagen type 1 (β-CTx) and their relationship with thyroid hormone levels and bone mineral density ( BMD) in adult patients under 50 years old with hyperthyroidism. Methods 150 adult patients under 50 years old with hyperthyroidism and 60 healthy adults in the same age range ( comparison group) were re-cruited to participate in the study. Subjects ’ BMD was assessed using the dual-energy X-ray absorptiometry (DXA) at forearm (whole radius), lumbar spine (L2~4), and femoral neck. The free triiodothyronine (FT3), free thyroxine ( FT4 ) and thyroid stimulating hormone ( TSH) in patients with hyperthyroidism were determined by chemiluminescence. The hyperthyroidism group was further divided into normal bone mass group ( ON group) , os-teopenia group ( OD group) and osteoporotic group ( OP group) based on T scores of BMD. Subjects’ PINP andβ-CTx levels were measured with ELISA, and their calcium ( Ca) and phosphorus ( P) were measured using an auto-matic biochemical analyzer. The levels of PINP,β-CTx, Ca and P were compared between the hyperthyroidism and comparison groups and among the three hyperthyroidism subgroups. Results When compared with comparison group, the hyperthyroidism group had significantly higher levels of PINP,β-CTx and Ca (P<0. 01), and signifi-cantly lower BMD at forearm, L2~4 and femoral neck ( P<0. 05 ) . Among patients with hyperthyroidism, the OP group had significantly higher PINP,β-CTx, FT3 and FT4 levels (P<0. 01) and significantly lower TSH level (P<0. 01) than the ON group had, and the OP group had significantly higher PINP,β-CTx, FT3 levels (P<0. 01) and significantly lower TSH level ( P <0. 01 ) than the OD group had. Besides, the OD group had significantly higher PINP, β-CTx levels ( P <0. 01 ) and significantly lower TSH level ( P <0. 01 ) than the ON group had. PINP and β-CTx levels were positively correlated with FT3 and FT4 levels ( P <0. 05 ) and negatively correlated with TSH and forearm BMD ( P<0. 05 ) in patients with hyperthyroidism. Conclusion Adult patients under 50 years old with hyperthyroidism have accelerated bone turnover, enhanced osteoclast function and increased osteo-blast activity. PINP and β-CTx in combination with BMD measurements can more accurately reflect the bone me-tabolisms in patients with hyperthyroidism.关键词
甲亢/骨质疏松/骨密度/PINP/β-CTxKey words
hyperthyroidism/osteoporosis/bone mineral density/PINP/β-CTx分类
医药卫生引用本文复制引用
陈玮,徐将,陈超,祝捷,王计艳,吴玉洁,董林,杨光伟,邢学农..中青年甲亢患者血清PINP、β-CTx与骨密度关系分析[J].安徽医科大学学报,2014,(6):804-807,4.基金项目
安徽省科技厅重点项目(编号:11070403029) （编号:11070403029）
