安徽医科大学学报Issue(7)：941-945,946,6.
抗幽门螺杆菌药物在大鼠胃内的分布和雷贝拉唑的影响
The transport of antibiotics used against Helicobacter pylori in rat stomach and the effects of rabeprazole
摘要
Abstract
Objective To explore the characteristic of amoxicillin and levofloxacin in the transport and distribution in rat stomach in the triple therapy including rabeprazole used against Helicobacter pylori ( H. pylori) and the effect of rabeprazole on their pharmacokinetics. Methods The model for exploring the antibiotics transport and distribu-tion in rat stomach was prepared. The different sample in rat including blood, the different region gastric mucosa, and the total gastric juice were obtained in the different time point after administration. The antibiotic concentra-tions in the different sample were surveyed by high performance liquid chromatography ( H. PYLORILC) . The sta-tistical analysis of the pharmacokinetics parameters of the drugs transport and distribution were carried out. Results The amoxicillin T1/2 in rat blood was 1 h or so. Rabeprazole did not significantly change the pharmacokinetic pa-rameters of amoxicillin in the plasma, and lengthened the levofloxacin T1/2 in the plasma. Amoxicillin concentration in rat stomach was lower significantly than that in the plasma. Levofloxacin concentration in rat gastric juice was higher than that in the plasma. The two antibiotics concentration in the forestomach mucosa was lower than that in the glandular stomach mucosa. The deviation of two antibiotics concentration in the different region of the glandular stomach mucosa was not statistical significance. Conclusion The antibiotic amoxicillin and levofloxacin used a-gainst H. pylori could penetrate the gastric mucosa into the stomach. The antibiotic concentration in gastric mucosa in the different regions is different. The active transport mechanism of the transporting levofloxacin could exist in the stomach. Rabeprazole could affect levofloxacin kinetic parameter in blood or gastric mucosa.关键词
雷贝拉唑/阿莫西林/左氧氟沙星/幽门螺杆菌Key words
rabeprazole/amoxicillin/levofloxacin/Helicobacter pylori分类
医药卫生引用本文复制引用
郑海伦,胡咏梅,鲍峻峻,许建明..抗幽门螺杆菌药物在大鼠胃内的分布和雷贝拉唑的影响[J].安徽医科大学学报,2014,(7):941-945,946,6.基金项目
国家自然科学基金(编号:81100269) （编号:81100269）
安徽省教育厅自然科学研究项目(编号:KJ2012B103) （编号:KJ2012B103）
