安徽医科大学学报Issue(7)：958-961,962,5.
HER-2、CyclinD1在甲状腺乳头状癌中的表达及意义
Expression and significance of HER-2 and CyclinD1 in papillary thyroid carcinoma
摘要
Abstract
Objective To explore the significance of HER-2 protein, CyclinD1 protein in papillary thyroid carcino-ma ( PTC) . Methods Immunohistochemical staining was performed in 97 specimens of PTC and 97 specimens of adjacent benign lesions to examine the expression of HER-2 protein and CyclinD1 protein. Results ① The posi-tive ratio of HER-2 in PTC was 46. 4%, and no expression in the adjacent benign lesions. There was statistical difference between them ( P <0. 05 ) . HER-2 expression correlated with tumor size in PTC. The expression of HER-2 had significant difference between less than or equal to 1 cm and greater than 1cm in diameter of PTC. There were no relationships between expression of HER-2 and other clinicopothological features in PTC. ② The positive ratio of CyclinD1 in PTC was 92. 8%, and no expression in the adjacent benign lesions. There was statisti-cal difference between them(P<0. 05). The sensitivity of CyclinD1 was 92. 8%, the specificity can reach 100%in PTC . There were no relationships between expression of CyclinD 1 and the clinicopothological features in PTC . CyclinD1 showed heterogeneity of expression in some patients’ carcinoma. ③There were no relationships between expression of HER-2 and CyclinD1 in PTC. Conclusion ① HER-2 plays an important role in the carcinogenesis of PTC. HER-2 could be a potential target for targeted therapy in PTC. ②CyclinD1 could be as molecular markers of early diagnosis in PTC. There could be positive correlation between CyclinD1 ’ s heterogeneity of expression of PTC and the lymph node metastases.关键词
甲状腺乳头状癌/HER-2/C-erbB-2/CyclinD1Key words
papillary thyroid carcinoma/HER-2/C-erbB-2/CyclinD1分类
医药卫生引用本文复制引用
张晓亮,胡向阳,杨懿,丁婧,汪巧..HER-2、CyclinD1在甲状腺乳头状癌中的表达及意义[J].安徽医科大学学报,2014,(7):958-961,962,5.基金项目
国家临床重点专科建设项目经费资助 （）
