安徽医科大学学报Issue(9)：1238-1241,4.
普萘洛尔治疗婴幼儿血管瘤作用机制的动物实验研究
An experimental study on the mechanism of therapy for hemangioma with propranolol
摘要
Abstract
Objective To discuss the effect of propranolol on the proliferation of human hemangioma on growth of planting tumor in nude mice. Methods Surgery on 1 case of proliferative phase for children strawberry hemangio-ma tissue fragments made from, respectively, 16 pups in nude mice implanted ( BALB/c nu/nu) under the skin on each of 4 . Establishment of nude mouse model of human hyperplastic vascular tumor was randomly divided into two groups on the 45th day:In general group of propranolol, propranolol was given with 0. 01% solution 0. 4 ml after intragastric infusion once a day for a week. In mice of control group, intragastric administration of the same volume of distilled water was given once a day for a week. The growth conditions of the nude mice and transplanted tumors were observed, using the method of immunohistochemistry and Western blot to detect the expression of vascular en-dothelial growth factor (VEGF) and insulin-like growth factor-2 (IGF-2). Results Experimental group in nude mice tumor volume in the intervening period was declined significantly, while the tumor size in the control group was increaseing. After intragastric administration of propranolol, the expression of VEGF and IGF-2 protein in graft tumor was decreased significantly. Conclusion Propranolol can inhibits the growth of human hemangioma growing speed in vivo and inhibits the secretion of VEGF and IGF-2. With decreased VEGF and IGF-2 secretion,the tumor angiogenesis is inhibited and the fade transition is accelerated.关键词
血管瘤/普萘洛尔/血管内皮生长因子/胰岛素样生长因子-2Key words
hemangioma/propranolol/vascular endothelial growth factor/insulin-like growth factor-2分类
医药卫生引用本文复制引用
丁涛,曹东升,谢娟,李红红,陈增红,朱邦中,鲍琼,娄寅..普萘洛尔治疗婴幼儿血管瘤作用机制的动物实验研究[J].安徽医科大学学报,2014,(9):1238-1241,4.基金项目
安徽省科技厅项目(编号:KJ2011Z190) （编号:KJ2011Z190）
