安徽医科大学学报Issue(9)：1291-1294,4.
右美托咪定对食管癌根治术患者单肺通气时肺内分流及动脉氧分压的影响
Effects of dexmedetomidine on intrapulmonary shunt and oxygen pressure of the artery during one-lung ventilation undergoing esophageal cancer resection
摘要
Abstract
Objective To observe the effects of dexmetomidine on OLV intrapulmonary shunt in and oxygen pres-sure of the artery during one-lung ventilation undergoing esophageal cancer resection. Methods A total of 40 pa-tients of ASA Ⅰ or II,aged 25~65 undergoing elective surgery were randomized into two groups of 20 each. Dex group and normal saline (NS) group. Dex group used Dex 0. 6 μg/kg within 10 min as a bolus and then main-tained at 0.4 μg/( kg·h) ,before the end of the operation 30 min. The same volume of NS was given in the same manner in NS group. Radial artery and internal jugular vein blood were collected and the blood gas were analyzed at five time points:after anesthesia induction at lateral position TLV 30 min( T1 ) ,OLV 30 min( T2 ) ,OLV 60 min ( T3 ) ,OLV 90 min( T4 ) ,recovering TLV 30 min( T5 ) ,and then calculating the intrapulmonary shunt and recorded oxygen pressure of the artery. Results There were no significant differences in hemodynamic parameters MAP and BIS between the two groups(P>0.05). PaO2 was significantly lower, while Qs/Qt was higher at T2~4 than at T1 in group Dex and NS(P<0.05);PaO2 was lower,while Qs/Qt was higher at T5 than at T1 in group NS(P<0.05);but there were no statistical differences in group Dex (P>0.05). PaO2 was higher,while Qs/Qt was lower at T5 in group Dex than in group NS ( P<0.05 ) . Conclusion Dex can improve intrapulmonary shunt and oxygen pressure of the artery significantly in esophageal cancer resection after recovering TLV.关键词
右美托咪定/单肺通气/肺内分流Key words
dexmedetomidine/one-lung ventilation/intrapulmonary shunt分类
医药卫生引用本文复制引用
张丽丽,张野,李云,翁立军,陈齐,蒋玲玲..右美托咪定对食管癌根治术患者单肺通气时肺内分流及动脉氧分压的影响[J].安徽医科大学学报,2014,(9):1291-1294,4.基金项目
安徽省科技厅年度重点项目(编号:1301043030) （编号:1301043030）
