安徽医科大学学报Issue(10)：1465-1467,1468,4.
氨磺必利对男性精神分裂症患者性功能和催乳素的影响
Effects of amisulpride on sexual function and prolactin secretion in male patients with schizophrenia
摘要
Abstract
Objective To investigate the influence of amisulpride treatment on sexual function and prolactin secre-tion in male schizophrenia. Methods 60 patients of schizophrenia were randomly divided into two groups, each of which received either amisulpride (30 cases) or aripiprazole(30 cases) treatment for 8 weeks. The Arizona sexual experience scale ( ASEX ) was self-evaluated before and after 8 weeks treatment , respectively . The positive and negative symptom scales ( PANSS ) were used to evaluate treatment efficacy while side effects were assessed by treatment emergent symptom scale ( TESS) and prolactin levels were measured in the same time. Results After 8 weeks treatment, ASEX scores, sex drive scores, sexually aroused scores, orgasms satisfying scores, prolactin lev-els were significantly higher than before in the patients receiving amisulpride. No significant difference was in arip-iprozole group. The therapeutic effects were nearly equivalent; and the side effects of both were weak. Prolactin levels had significantly positive correlation with ASEX scores within the whole patients and amisulpride group after 8 weeks treatment. No significant correlation was detected between amisulpride dosage and either sex function or pro-lactin levels . Conclusion Amisulpride has stronger effects in sexual function and serum prolactin of male schizo-phrenia patients.关键词
氨磺必利/阿立哌唑/精神分裂症/性功能障碍/催乳素Key words
amisulpride/aripiprozole/schizophrenia/sexual dysfunction/prolactin levels分类
医药卫生引用本文复制引用
程林,李泽爱,朱春燕,潘多..氨磺必利对男性精神分裂症患者性功能和催乳素的影响[J].安徽医科大学学报,2014,(10):1465-1467,1468,4.基金项目
国家自然科学基金(编号:31100812) （编号:31100812）
