安徽医科大学学报Issue(1)：62-65,4.
ER-β在骨转移为首发的非小细胞肺癌中的表达
The expression of ER-βin NSCLC with symptoms of bone metastases at time of diagnosis
摘要
Abstract
Objective To analyze the relationship between ER-β and clinical prognosis by detecting its expression in NSCLC with symptoms of bone metastases at the time of diagnosis. Methods The expression of ER-βin tissues was investigated by immunohistochemistry. The differences between groups were analyzed by chi-square test. The survival rates were calculated using the Kaplan-Meier method. The log-rank method was used for univariate analy-sis, and the Cox regression model was used for multivariate analysis. Results The positive percentage of ER-βex-pressed in 46 NSCLC patients with bone metastases at the time of diagnosis was 78. 3 %. The expression of ER-βhad no difference among groups of sex, age, tumor subtype, number of bone metastases, more than one bone me-tastasis, ALK, CEA. Chi-square test did not find statistical differences of ER-βexpression among groups. Multiva-riate analysis showed that ER-βwas an independent predictor of overall survival (OS) (P=0. 035). Univariate a-nalysis showed that the patients who had ER-β positive expression had longer survival time ( P<0. 05 ) . The pa-tients with lung adenocarcinoma or NSCLC with single bone metastasis who present with ER-β positive expression had a significant superior survival rate to ER-β negative expression patients ( P<0. 05 ) . Conclusion Higher ex-pression of ER-β was found in NSCLC patients with bone metastases at time of diagnosis. The patients with ER-βpositive expression have a favorable prognosis, and it may be an independent prognosis predictor of these patients. In addition, ER-β positive expression may be closely related with OS of NSCLC patients who have single bone me-tastasis or adenocarcinoma.关键词
骨转移癌/非小细胞肺癌/ER-βKey words
bone metastasis/NSCLC/ER-β分类
医药卫生引用本文复制引用
罗会芹,胡冰,季楚舒,何义富,姚艺玮,闫滢,吴书胜,胡小秀,柯丽红,牛佳郁,李慧敏..ER-β在骨转移为首发的非小细胞肺癌中的表达[J].安徽医科大学学报,2015,(1):62-65,4.基金项目
安徽省自然科学基金(编号:1408085MH179) （编号:1408085MH179）
安徽省卫生厅医学科研课题(编号:13zc012) （编号:13zc012）
