安徽医科大学学报Issue(1)：91-93,94,4.
慢性肾脏病患者血清骨保护素水平及与腹主动脉钙化的相关性分析
Relationship between serum osteoprotegerin and abdominal aortic calcification
摘要
Abstract
Objective To determine serum osteoprotegerin ( OPG) level in chronic kidney disease( CKD) and its relationship with abdominal aortic calcification (AAC). Methods Eighty-six patients with CKD 3-5D were recrui-ted in the study. The level of serum OPG was measured by enzyme-linked immunlsorbent assay. AAC score was as-sessed by abdominal lateral X-ray examination. Results According to the presence of AAC, the patients with CKD3-5D were divided into two groups, AAC group (n=51) and non-AAC group (n=35). Serum OPG in group AAC was relatively higher than that in non-AAC group ( P =0. 004 ) , serum OPG ( 13. 41 ± 2. 46 ) ng/ml versus OPG(11. 04 ± 2. 75) ng/ml. The level of serum OPG in CKD5 patients was higher than in CKD3-4 patients (P<0. 05), serum OPG (11. 75 ± 2. 85) ng/ml versus OPG (10. 39 ± 2. 78) ng/ml. But there was no difference be-tween predialysis CKD5 and CKD5D patients. The level of serum OPG was significantly associated with eGFR(r=-0. 357,P=0. 011),AAC degree(r=0. 258, P=0. 017). Logistic analysis showed that male (β=2. 568, P=0. 048), smoking habits(β=4. 337, P=0. 013)and OPG (β=1. 273, P=0. 003) were associated with moderate to severe AAC. Conclusion The level of serum OPG is higher in patients with CKD5 than that of CKD3-4. The results suggest that higher OPG maybe play an important role in AAC progression.关键词
骨保护素/慢性肾脏病/腹主动脉钙化Key words
osteoprotegerin/chronic renal disease/abdominal aortic calcification分类
医药卫生引用本文复制引用
王雪荣,王德光,袁亮,何衡杰,刘桂凌,张晶晶,王瑞峰,郝丽..慢性肾脏病患者血清骨保护素水平及与腹主动脉钙化的相关性分析[J].安徽医科大学学报,2015,(1):91-93,94,4.基金项目
高校省级自然科学研究项目(编号:KJ2013Z155) （编号:KJ2013Z155）
