安徽医科大学学报Issue(2)：194-197,4.
18 F-FDG PET/CT显像在评价不同病理亚型淋巴瘤疗效方面的价值
Significance of 18 F-FDG PET/CT imaging in evaluating curative effect of different pathologic subtypes of lymphoma
摘要
Abstract
Objective The purpose of this study was to identify the roles of 18 F-FDG PET/CT imaging in evaluating the therapeutic efficacy of lymphoma with different pathologic subtypes. Methods Patients with lymphoma who had received PET/CT check in pre-therapy and post-therapy for nearly four years were recruited in this study. Patients with lymphoma who had received such checks before treatment were also randomly selected voluntarily, and another PET/CT imaging was performed on them after 2~4 courses of treatment. Finally, the pre-therapy and post-treat-ment maximumstandardized uptake value ( SUVmax) or retention index ( RI) of 43 lymphoma lesions with different subtypes ( including the lymph gland lesion and the extranodal lesion) were analyzed, comparing both retrospective-ly and statistically. In addition, all patients received a follow-up at least 3 months. Results By comparison, there was no significant difference in the RI and the average SUVmax between Hodgkin lymphoma ( HL ) lesions and Non-Hodgkin lymphoma ( NHL) lesions before treatment. Besides, the RI and the average SUVmax of NHL lym-phoma lesions with different subtypes had a positive relation to NHL invasiveness before treatment. However, no obvious relation existed between the RI and the average SUVmax of NHL lymphoma lesions and the periodization of lymphoma. After treatment, 23 of the 43 patients showed complete remission, 16 patients showed partial remission, 1 patient had stable disease, and 3 had relapsed disease/progressive disease. In a word, the SUVmax differences of lymphoma lesions before and after the treatment had significant statistical significance ( P<0. 01 ) . Conclusion With regard to the comparative analysis of average SUVmax and RI before and after lymphoma lesion treatment, 18 F-FDG PET/CT imaging can evaluate the curative effects and prognosticate diseases effectively,and provide assis-tance and guidance for the formulation of a further therapeutic schedule as well.关键词
淋巴瘤/18 F-FDG/PET/CT/SUVmax/滞留指数/疗效评价Key words
lymphoma/18 F-FDG/PET/CT/SUVmax/retention index/curative effect evaluation分类
医药卫生引用本文复制引用
何延辉,徐慧琴,汪会,余文静,赵学峰,余永强..18 F-FDG PET/CT显像在评价不同病理亚型淋巴瘤疗效方面的价值[J].安徽医科大学学报,2015,(2):194-197,4.基金项目
安徽省科技厅第三批年度重点项目(编号:1301043021) （编号:1301043021）
