安徽医科大学学报Issue(2)：202-205,4.
Graves′病患者CD4+ CD25+调节性T细胞功能初探
Study on the function of CD4+ CD25+ regulatory T cells in patients with Graves’ disease
摘要
Abstract
Objective To investigate the role of regulatory T cells( Tregs) in Graves’ disease ( GD) . Methods Treg number was assessed by flow cytometric analysis in samples from 20 GD patients and 10 healthy controls. The inhibitory effect of Treg on T effector cells(Teff) was assayed by 3H thymidine proliferation experiment. IL-10,IL-2 and other cytokine levels were determined by ELISA in conditioned media from the co-cultures. Results No differ-ences were found in the frequency of Tregs as a percentage of CD4 + cells between GD and healthy controls. Com-pared with the healthy controls, inhibitory function of Treg from patients with GD decreased significantly. Cytokine secretion between two groups also had significant difference. IL-10 secretion of healthy control group was signifi-cantly higher than patients group, while secretion of IL-2 and IL-17 was significantly lower than patients group. Conclusion Tregs from GD patients are partly dysfunctional, possibly explaining their autoimmunity. Future work will elucidate the diagnostic potential and pathophysiology of Tregs in GD.关键词
Graves’病/调节性T细胞/效应T细胞Key words
Graves’ disease/regulatory T cells/T effector cells分类
医药卫生引用本文复制引用
孙伟莉,申勇,李卫鹏,袁媛,张林杰..Graves′病患者CD4+ CD25+调节性T细胞功能初探[J].安徽医科大学学报,2015,(2):202-205,4.基金项目
安徽省高校省级自然科学基金(编号:KJ2011A167) （编号:KJ2011A167）
