安徽医科大学学报Issue(2)：227-230,231,5.
HIF-1α、VEGF、VEGFR-1、VEGFR-2在稽留流产患者绒毛组织中的表达
The expression and significance of HIF-1α,VEGF, VEGFR-1 and VEGFR-2 in missed abortion patients
摘要
Abstract
Objective To study the expressions and clinical significance of hypoxia inducible factor-1α( HIF-1α) ,vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-1 (VEGFR-1) and vascular endothelial growth factor receptor-2 (VEGFR-2) in the villi tissue of patients with missed abortion (MA) and early pregnant women. To explore the influence of hypoxia on placenta angiogenesis in missed abortion. Methods To de-tect the expression of HIF-1α,VEGF,VEGFR-1 and VEGFR-2 in the villi tissue of 35 cases of MA patients( re-search group) and 32 early pregnant women( control group) who underwent induced abortion surgery by immuno-histochemistry,and the results were statistical analysis. Results HIF-1α,VEGF,VEGFR-1 and VEGFR-2 were ex-pressed both in the villi tissue of research group and the control group. The expression of HIF-1α was higher in the research group than in the control group(P<0. 05). The expressions of VEGF,VEGFR-2 were significantly lower in the research group than in the control group ( P<0 . 05 ); the expression of HIF-1α was positively correlated with VEGF,VEGFR-1and VEGFR-2 in the control group, and the expression of HIF-1α was negatively correlated with VEGF and VEGFR-2 in the research group (P<0. 05),which had no correlation with VEGFR-1. Conclusion The expression of HIF-1α in the villi tissue of MA is up-regulated, the blood vessel formation of placenta decreases by adjusting the VEGF and VEGFR-2 genes transcription,which maybe is the important causes for MA.关键词
稽留流产/低氧诱导因子/血管内皮生长因子/血管内皮生长因子受体Key words
HIF-1α/VEGF/VEGFR-1/VEGFR-2/missed abortion分类
医药卫生引用本文复制引用
王玲,赵卫东..HIF-1α、VEGF、VEGFR-1、VEGFR-2在稽留流产患者绒毛组织中的表达[J].安徽医科大学学报,2015,(2):227-230,231,5.基金项目
安徽省科技攻关计划项目(编号:08010302101) （编号:08010302101）
