安徽医科大学学报Issue(3)：368-371,372,5.
Peroxiredoxin 1与EMT相关蛋白在胰腺癌组织中的表达及其临床意义
Clinical significance of expression of Peroxiredoxin 1 and EMT related factors in pancreatic carcinoma
摘要
Abstract
Objective To investigate the expression clinical significance of Peroxiredoxin 1 ( Prx1 ) and epithelial mesenchymal transition (EMT)-related factors in pancreatic carcinoma. Methods The expression of Prx1, E-cad-herind and Vimentin were detected in 66 pancreatic carcinoma samples and 11 normal pancreatic tissues by immu-nohistochemical method. The correlation between Prx1, E-cadherin, Vimentin and clinicopathologic characteristics was also analyzed. Results The positive expression rates of Prx1, E-cadherind and Vimentin were 69. 70% (46/66), 40. 91% (27/66) and 56. 06% (37/66) in pancreatic carcinoma, and 18. 18% (2/11), 90. 90% (10/11) and 18. 18% (2/11) in normal pancreatic tissue, respectively. The expression rates of Prx1, E-cadherin and Vimentin were correlated with TNM stage, lymph node metastasis, degree of differentiation ( P <0. 05 ) . Prx1 expression was correlated with nerve invasion in pancreatic carcinoma tissue ( P<0. 05 ) . The expression rates of <br> Prx1, E-cadherin and Vimentin were not correlated with sex, age, size, site of tumor. E-cadherin and Vimentin expression were not correlated with nerve invasion inpancreatic carcinoma tissue. Prx1 expression in pancreatic car-cinoma was positively correlated with Vimentin expression ( P<0. 05 );Prx1 and Vimentin were negatively correla-ted with E-cadherin expression ( P<0. 05 ) . Conclusion Prx1 , E-cadherin and Vimentin expressions are associ-ated with the ability of invasion and metastasis in pancreatic carcinoma, Prx1 abnormal expression maybe serve as a potential poor prognostic marker of patients with pancreatic carcinoma.关键词
胰腺癌/过氧化物还原酶1/E-钙黏素/波形蛋白Key words
pancreatic carcinoma/Peroxiredoxin 1/E-cadherind/Vimentin分类
医药卫生引用本文复制引用
蔡重阳,汤志刚,黄强,陈炯,潘婷婷,翟路路..Peroxiredoxin 1与EMT相关蛋白在胰腺癌组织中的表达及其临床意义[J].安徽医科大学学报,2015,(3):368-371,372,5.基金项目
国家自然科学基金(编号:81272740) （编号:81272740）
