安徽医科大学学报Issue(4)：533-536,537,5.
狼疮性肾炎患者HMGB1和RAGE的表达及意义
Expression and significance of HMGB1 and RAGE in patients with lupus nephritis
叶莉莉 1徐星铭1
作者信息
- 1. 安徽医科大学第一附属医院肾脏内科，合肥 230022
- 折叠
摘要
Abstract
Objective To explore the role of high mobility group box protein 1 ( HMGB1 ) and receptor for ad-vanced glycation endproducts( RAGE) in lupus nephritis( LN) . Methods The serum and urine levels of HMGB1 were detected by ELISA in SLE patients and normal controls, and intrarenal expressions of HMGB1 and RAGE were detected by immunohistochemistry in renal tissues of SLE patients and normal-appearing renal tissues. Results <br> The serum and urine levels of HMGB1 were significantly higher in SLE patients compared to healthy controls( P<0. 01 ) , in patients with active disease compared to those with inactive disease ( P <0. 05 ) , serum levels of HMGB1 were found to be significantly higher in patients with renal involvement compared to those without renal in-volvement(P<0. 05). In addition, the levels of serum HMGB1 showed positive correlation with SLEDAI,urine pro-tein(24 h) and lencocyte count (P <0. 05). The expression of urine HMGB1 showed positive correlation with SLEDAI ( P<0. 05 ) . Intermediate-intensity staining of HMGB1 and RAGE was detected in renal tubules in normal-appearing renal tissues, however, both renal tubules and glomerular cells had the strong expression of HMGB1 and RAGE in SLE patients. The intrarenal production of HMGB1 and RAGE in SLE patients was obviously higher than that in normal-appearing renal tissues(P<0. 05), and the expression levels of HMGB1 in SLE IV and IV+V were higher than those in SLE II ( P<0. 05 ) . The expression levels of RAGE in SLE IV were higher than those in SLE II(P<0. 05). Conclusion HMGB1 and RAGE may play key roles in the pathogenesis of LN and may associate with the pathology category of LN.关键词
系统性红斑狼疮/狼疮性肾炎/高迁移率族蛋白B1/晚期糖基化终产物受体Key words
systemic lupus erythematosus/lupus nephritis/high mobility group box protein 1/advanced glycation endproducts分类
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叶莉莉,徐星铭..狼疮性肾炎患者HMGB1和RAGE的表达及意义[J].安徽医科大学学报,2015,(4):533-536,537,5.
