安徽医科大学学报Issue(5)：628-631,4.
自噬相关蛋白 LC3-Ⅱ在上皮性卵巢癌中的表达及临床意义
Expression and clinical significance of autophagy-related LC3-Ⅱ in epithelial ovarian cancer
摘要
Abstract
Objective To investigate the expression of microtubule-associated protein light chain 3-Ⅱ(LC3-Ⅱ) in the epithelial ovarian carcinoma and explore their correlations to the tumorigenesis and development of epithelial o-varian carcinoma. Methods 204 specimens with different-type epithelial ovarian tumors,including 46 with serous cystadenoma,28 with borderline serous cystadenoma,40 with serous cystadenocarcinoma,32 with mucinous cystade-noma,32 with borderline mucinous cystadenoma,28 with mucinous cystadenocarcnoma,were selected in our study. Immunohistochemistry was employed to detect the expression of LC3-Ⅱ. The correlations between expression of LC3-Ⅱ and both the pathological features and clinical manifestations of 68 epithelial ovarian cancer patients were analyzed. Results The positive rates of LC3-Ⅱ were significantly higher in epithelial ovarian cancinoma and bor-derline ovarian tumors than benign epithelial ovarian tumors. (In ovarian serous tumor,95% and 71% vs 4. 5% ,P< 0. 01;in ovarian mucinous tumor, 92. 9% and 66. 7% vs 6. 7% ,P < 0. 01) ② In the serous cystadenocarcinoma and mucinous cystadenocarcnoma,the expression of LC3-Ⅱ was not correlated to age, FIGO stage and histological grade. Conclusion Expression of LC3-Ⅱ is up-regulated in epithelial ovarian cancer tissues. The increase of au-tophagic capacity may relate to the development of epithelial ovarian cancer.关键词
卵巢肿瘤/自噬/LC3-ⅡKey words
ovarian neoplasm/autophagy/LC3-Ⅱ分类
医药卫生引用本文复制引用
于婷,赵洪萍,周颖,赵卫东,刘培淑..自噬相关蛋白 LC3-Ⅱ在上皮性卵巢癌中的表达及临床意义[J].安徽医科大学学报,2015,(5):628-631,4.基金项目
国家自然科学基金(编号:81001168、81272881) （编号:81001168、81272881）
安徽省科技厅年度重点科研项目(编号:1301043053) （编号:1301043053）
