安徽医科大学学报Issue(6)：770-774,5.
CyPA 及 CD147在动脉粥样硬化兔血管重构中的表达
Expressions of CyPA and CD147 in vascular remodeling of atherosclerosis rabbits
摘要
Abstract
Objective To explore the expressions of Cyclophilin A( CyPA)/ CD147 in vascular remodeling of ath-erosclerosis(AS)rabbits. Methods 32 healthy male New Zealand rabbits(3 months)were randomly divided into the control group,model group,cold-induced injury group,hyperlipid group(8 in each group). Expressions of CyPA and CD147 in serum of rabbits were tested at the beginning and the 13th week,respectively. All rabbits were sacrificed after 13 weeks. Then paraffin-embedded sections were used for HE staining and special staining for elas-tic fiber to analyze the changes of vascular morphology. Additionally,macrophagocyte / CyPA/ CD147 monoclonal antibodies were applied to immunohistochemistical staining and the changes of related vascular remodeling indexes after arterial injury were observed using computerized image analyzing system. Results The expressions of CyPA and CD147 in serum increased significantly in the model group,cold-induced injury group and hyperlipid group compared with those in control group at 13th week(P < 0. 05),respectively,especially the model group. Hyper-plastic intima was found in the model group,cold-induced injury group and hyperlipid group,but not in the control group. Additionally,atherosclerotic plaque could be found in the model group. There were high expressions of CyPA and CD147 in atherosclerotic plaques and hyperplastic intima in the model group,also in the cold-induced in-jury group and hyperlipid group. The minimum lumen diameter and lumen area significantly decreased in these three group compared with the control group(P < 0. 05). However,the intima area,media area,maximum intima thickness and lumen stenosis increased significantly( P < 0. 05). Conclusion High expressions of CyPA and CD147 are found in Remodeling Vascular of atherosclerosis rabbits.关键词
动脉粥样硬化/亲环素 A/CD147/血管重构Key words
atherosclerosis/cyclophilin A/CD147/vascular remodeling分类
医药卫生引用本文复制引用
张雁斌,杜大勇,李运田,柳杨,李桂明,李沫言,王新亮,路怀志,杨升华..CyPA 及 CD147在动脉粥样硬化兔血管重构中的表达[J].安徽医科大学学报,2015,(6):770-774,5.基金项目
全军“十一五”医药卫生科研基金资助项目 （）
