安徽医科大学学报Issue(6)：821-824,825,5.
PD-L1和 PD-1在胃癌组织中的表达及其临床意义
Expression and clinical significance of PD-L1 and PD-1 in gastric carcinoma
摘要
Abstract
Objective To investigate the correlation between the expression of costimulatory molecule programmed death ligand 1(PD-L1),as well as its receptor programmed death 1(PD-1)in gastric carcinoma and clinicopatho-logic features. Methods The study comprised tumor sections from 151 gastric cancer patients treated with curative resection,74 matched lymph nodes,and 20 cases of adjacent normal tissues controls,which were evaluated for PD-L1 and PD-1 protein expression by immunohistochemistry. Results PD-L1 and PD-1 expression were increased in cancers compared to adjacent normal tissues,with positive rate of 60. 93% and 38. 41% ,respectively. Meanwhile, expressions of PD-L1 and PD-1 were highly correlated between the primary tumors and metastatic nodes,with con-cordance rates of 82. 43% and 87. 84% for PD-L1 and PD-1,respectively. PD-L1 expression in gastric carcinoma was not correlated with PD-1 expression in lymphocyte. Expression of PD-L1 was significantly correlated with some clinicopathologic features including stage,depth of invasion,lymph node metastasis and vascular metastasis(P <0. 05),but not PD-1. Conclusion PD-L1 and PD-1 are overexpressed in gastric cancer tissues. PD-L1 expres-sion plays a critical role in the pathogenesis of human gastric cancer,suggesting that it might be used as a new bio-marker to predict the disease progression and prognosis.关键词
胃肿瘤/PD-L1/PD-1/免疫逃逸Key words
gastric cancer/PD-L1/PD-1/immune evasion分类
医药卫生引用本文复制引用
吴圣,邵婧怡,王芳,范璐璐,孙国平..PD-L1和 PD-1在胃癌组织中的表达及其临床意义[J].安徽医科大学学报,2015,(6):821-824,825,5.基金项目
国家自然科学基金（编号81272739）；安徽省科技攻关项目 （）
