安徽医科大学学报Issue(6)：850-854,5.
右美托咪定复合舒芬太尼在下肢骨折患者术后静脉自控镇痛中的应用
Effect of sufentanil combined with dexmedetomidine on postoperative patient-controlled intravenous analgesia in patients undergoing lower limb fracture surgery
摘要
Abstract
Objective To investigate the effect of combining dexmedetomidine(Dex)and sufentanil on postopera-tive patient-controlled intravenous analgesia(PCIA)in patients of lower limb fracture. Methods One hundred and fifty patients,ASAⅠ ~ Ⅱ,undergoing lower limb fracture surgery,were randomly divided into five groups:different doses of sufentanil groups(S1,S2 group)and sufentanil combining with different doses of dexmedetomidine groups (M1,M2,M3 group). At the end of the surgery,patients immediately received postoperative PCIA. All drugs were diluted with saline to 100 ml. PCIA was set as follows:background infusion 2 ml/ h;bolus dose 0. 1 μg / kg;PCA dose 0. 5 ml;loekout interva 15 min. The scores of VAS and RSS were recorded at 1,3,6,12,24 and 48 hours after PCIA. The press number,dezocine consuming and the incidence rate of the nausea,vomiting,pruritus,respiratory depression and hypotension were recorded for 48 hours. Results Compared with group S1,M1,the VAS score was significantly decreased at T1 ~ T6 in S2,M2,M3(P < 0. 05). The RSS score was significantly increased at T1~ T6 in M3(P < 0. 05). The press number,and dezocine consuming was significantly decreased at T1 ~ T6 in S2, M2,M3(P < 0. 05). There were no complications in group M2. The occurrence of nausea,vomiting,pruritus,re-spiratory depression was significantly decreased in S1,M1,M2,M3 than S2(P < 0. 05). Compared with S1,the oc-currence of nausea and vomiting was significantly decreased in M2,M3(P < 0. 05). The occurrence of respiratory depression in M3 Group was significantly higher than M2 group(P < 0. 05). The occurrence of hypotension in M3 Group was significantly higher than other groups(P < 0. 05). Conclusion Sufentanil 2 μg / kg plus Dex 2 μg / kg has better satisfactory analgesia effect and less side effect. It is a better compound for orthopaedic.关键词
右美托咪定/舒芬太尼/术后镇痛/患者自控静脉镇痛/效果Key words
dexmedetomidine/sufentanil/postoperative analgesia/patient-controlled intravenous analgesia/effect分类
医药卫生引用本文复制引用
李明峡,胡宪文,张琪,肖建军,刘松,李熹,何淑芳,张野..右美托咪定复合舒芬太尼在下肢骨折患者术后静脉自控镇痛中的应用[J].安徽医科大学学报,2015,(6):850-854,5.基金项目
国家自然科学基金青年科学基金项目 （）
