安徽医科大学学报Issue(6)：867-869,3.
新疆维吾尔族 MT1XT20基因与微卫星不稳定结直肠癌相关性研究
The association study between Xinjiang Uygur people MT1XT20 gene and microsatellite instability colorectal cancer
摘要
Abstract
The microsatallite(MSI)stability of cancer and adjacent normal tissues was detected in 43 cases of Xinjiang Uygur patients with colorectal cancer after resection and the relationship between the MT1XT20 gene and the incidence of MSI colorectal cancer in Xinjiang Uygur people was discussed. The polymerase chain reaction -single strand conformation polymorphism( PCR-SSCP)technique was used for the detection and analysis of the Xinjiang Uygur MT1XT20 gene and MSI colorectal cancer. In 43 Xinjiang Uygur patients,24 cases had microsatel-lite alterations,with the total detection rate of 55. 81% ,8 cases sent a microsatellite alteration and 16 cases had more than two locus alterations. However,no microsatellite alteration was found in adjacent normal tissues. There was a high frequency of microsatellite alteration at the MT1XT20 locus,suggesting a close relationship between MT1XT20 gene and the incidence of colorectal cancer in Xinjiang Uygur people,thus providing a significant meas-ure for the early diagnosis of MSI colorectal cancer.关键词
结直肠癌/微卫星不稳定/MT1XT20基因Key words
colon carcinoma/microsatellite instability/MT1XT20 gene分类
医药卫生引用本文复制引用
吴静,龚旭晨,孔长青,赵宗峰..新疆维吾尔族 MT1XT20基因与微卫星不稳定结直肠癌相关性研究[J].安徽医科大学学报,2015,(6):867-869,3.基金项目
新疆维吾尔自治区人民医院院内基金 （）
