安徽医科大学学报Issue(7)：969-972,973,5.
白藜芦醇对佐剂性关节炎大鼠血管内皮因子表达的影响
Effect of resveratrol on expression of VEGF in rats with adjuvant arthritis
摘要
Abstract
Objective To investigate the effect of anti-inflammatory and expression level of vascular endothelial growth factor( VEGF) of resveratrol ( Res) on synovial tissues in rats with adjuvant arthritis ( AA) . Methods 60 SD rats were randomly divided into two groups:normal group (10 rats) , model group (50 rats) . Model group was injected freund′s complete adjuvant induced arthritis, when the right paw was induced after 12 days and secondary immune-inflammatory feet were swollen,the model rats were randomly divided into 5 groups, and each group had 10 rats AA model,Res low dose group(5 mg/kg) , Res middle dose group(15 mg/kg) , Res high dose group(30 mg/kg),positive control celecoxib group (5 mg/kg) qd × 16. After induced inflammatory paw, the expressions of VEGF in synovial tissue and articular cartilage was detected by immunohistochemistry, VEGF protein content in synovial tissue were detected by Western blot. Results Res could inhibit model group rats pathological damage, compared with the AA model group, synovial tissue expression of VEGF was significantly low in the resveratrol-trea-ted groups and celecoxib group. Conclusion Res prevents the pathological changes of the joint degeneration, its mechanism may be invovled regulating the expression of VEGF in synovial tissue of AA rats.关键词
佐剂性关节炎/白藜芦醇/血管内皮因子/大鼠Key words
adjuvant arthritis/resveratrol/vascular endothelial growth factor/rats分类
医药卫生引用本文复制引用
卢锦森,马中飞,纵何香,叶桂萍,郭利梅,何舒宁,张梦琳,陈晓宇..白藜芦醇对佐剂性关节炎大鼠血管内皮因子表达的影响[J].安徽医科大学学报,2015,(7):969-972,973,5.基金项目
国家自然科学基金(编号:81373421) （编号:81373421）
国家级大学生创新创业训练计划项目(编号:201310366007) （编号:201310366007）
