安徽医科大学学报Issue(8)：1119-1123,1124,6.
白藜芦醇对小鼠酒精性脂肪肝的防治作用及机制研究
Protective effects and the potential mechanism of resveratrol on alcoholic fatty liver in mice
摘要
Abstract
Objective To evaluate the protective effects of resveratrol (RSV) on alcoholic fatty liver (AFL) mice, and investigate the potential molecular mechanism. Methods We conducted vivo studies in C57BL/ 6J mice fed with ethanol Lieber-DeCarli liquid diet and treated with RSV (10, 30, 100 mg / kg) and GSH (200 mg / kg). Re-sults The results showed that RSV (30 or 100 mg / kg) treatment significantly attenuated hepatic steatosis with lowering activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and levels of he-patic triglyceride (TG), increasing superoxide dismutase (SOD) activities, decreasing malondialdehyde (MDA) content, although the levels of serum TG were not changed significantly. Immunohistochemistry analysis and HE staining showed that RSV suppressed the expression of adipose differentiation-related protein (ADRP) and reduced hepatic lipid accumulation. Western blot analysis showed that RSV stimulated AMP-activated protein kinase (AMPK) activity and inhibited lipin1 expression. Conclusion RSV has protective effects on alcoholic fatty liver, and the potential mechanism might be involved in activation of AMPK-lipin1 signaling and its antioxidant roles.关键词
白藜芦醇/酒精性脂肪肝/腺苷酸激活蛋白激酶/脂素Key words
resveratrol/alcoholic fatty liver/AMPK/lipin1分类
医药卫生引用本文复制引用
陈毅,胡成穆,唐丽英,李浩,李俊..白藜芦醇对小鼠酒精性脂肪肝的防治作用及机制研究[J].安徽医科大学学报,2015,(8):1119-1123,1124,6.基金项目
安徽医科大学博士科研经费资助计划项目(编号:XJ201209) （编号:XJ201209）
安徽医科大学校科学研究基金资助项目(编号:2012xkj092) （编号:2012xkj092）
