安徽医科大学学报Issue(8)：1150-1153,1154,5.
34例不明原因发热起病 MPO-ANCA 阳性患者随访分析
A follow up study in 34 patients with MPO-ANCA positive caused by fever of unknown origin
摘要
Abstract
Objective To preliminarily investigate and discuss the clinical significance of positive myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) in patients with fever of unknown origin(FUO). Methods Thirty-four patients suffered from FUO with MPO-ANCA positive were enrolled in this study. The clinical data and their condition changes during the procedures diagnosis, treatment and follow-ups were recorded and analyzed. Re-sults 9 in 34 patients were deemed as infection-associated MPO-ANCA positive (group A) while the rest 25 pa-tients were developed to typical ANCA-associated vasculitis ( AAV) ( group B). Comparison between the two groups showed that the differences of blood sedimentation (P = 0. 002), serum ferritin(P = 0. 002) and MPO-AN-CA level ( P = 0. 001) in group B had statistical significance. Patient′ s Birmingham vasculitis activity score (BVAS) (P = 0. 002) and number of damaged organs (P = 0. 044) in group B were higher than those of group A, of which the renal dysfunction was even more significant in group B, showing in serum creatinine (P = 0. 005). There was a significant correlation (P = 0. 036) between MPO-ANCA and BVAS in group B while it was not signifi-cant (P = 0. 503) in group A. Compared with group B, patients'AAV conditions seemed mildly and easily to con-trol in group A after positively dealing with relevant etiological factors. Conclusion It will contribute to etiological diagnoses by testing MPO-ANCA in patients with FUO. MPO-ANCA positive in majority of patients with FUO is an early symptom of typical MPO-AAV. Minority may be induced by other diseases (infection and drugs, etc. ). It will be positively treated after confirmation. It is very important to make sure of a reasonable treatment regimen.关键词
抗中性粒细胞胞质抗体/抗髓过氧化物酶抗体/ANCA 相关性血管炎/不明原因发热Key words
anti-neutrophil cytoplasmic antibodies/antimyeloperoxidase antibodies/ANCA-associated vasculitis/fever of unknown origin分类
医药卫生引用本文复制引用
胡子盈,帅宗文,张铭明,陈珊宇..34例不明原因发热起病 MPO-ANCA 阳性患者随访分析[J].安徽医科大学学报,2015,(8):1150-1153,1154,5.基金项目
中华医学会临床医学科研专项基金(编号:08010290107) （编号:08010290107）
