按摩与康复医学Issue(9)：136-138,139,4.
壮腰通痹汤对大鼠腰椎间盘退变模型基质金属蛋白酶及组织形态学的影响
Effects of Zhuangyao Tongbi Decoction on Matrix Metalloproteinases and Histomorphology of Lumbar Disc Degeneration of Rat Model
摘要
Abstract
Objective:To observe the effects of Zhuangyao Tongbi decoction on matrix metalloproteinases and histomorphology of lumbar disc degen-eration of rat model, and explore the mechanism of Zhuangyao Tongbi Decoction for degenerative lumbar disc disease. Methods:18 SD rats were randomly divided into blank group, model group and decoction group, establishing rat model of intervertebral disc degeneration with anulus punc-ture, after 2 weeks of gastric gavage of Zhuangyao Tongbi decoction, ELISA method was used to measure the serum concentration of MMP-1, MMP-3 and TIMP-1, intervertebral disc tissue with HE staining. Results:MMP-1 and MMP-3 concentrations of model group were higher than those of blank group (P<0.05), MMP-1 and MMP-3 concentration of decoction group were significantly lower than those of model group (P<0.05), and TIMP-1 concentration of decoction group was significantly higher than that of blank and model group (P<0.05); according to HE staining, model group had obvious pathological changes, decoction group showed that pathological injury of intervertebral disc tissue had certain repair capability. Conclusion:Zhuangyao Tongbi decoction can improve the self-repairing capability of intervertebral disc tissue, the protective effect of intervertebral disc is likely to be achieved according to regulating abnormal MMP-1, MMP-3 amd TIMP-1.关键词
腰椎间盘退变性疾病/壮腰通痹汤/基质金属蛋白酶/组织形态学Key words
degenerative lumbar disc disease/Zhuangyao Tongbi Decoction/matrix metalloproteinase/histomorphology分类
医药卫生引用本文复制引用
潘泳鸿,陈少清,林建平,郑其开,陈艺敏,陈乐春,苏友新..壮腰通痹汤对大鼠腰椎间盘退变模型基质金属蛋白酶及组织形态学的影响[J].按摩与康复医学,2015,(9):136-138,139,4.基金项目
福建省自然科学基金项目，编号2014J01346；福建省教育厅A类科技项目，编号JA13163；福建省卫生厅青年科研课题，编号2013-2-70 （）
