北华大学学报（自然科学版）Issue(3)：358-361,4.DOI:10.11713/j.issn.1009-4822.2014.03.019
周剂量顺铂和奈达铂同步放疗治疗中晚期宫颈癌72例临床分析
Clinical Study on 72 Cases of Concurrent Chemoradiotherapy with the Same Dose of Cisplatin Versus Nedaplatin for Advanced Cervical Cancer
摘要
Abstract
Objective To investigate the efficacy and adverse reactions of three dimentional conformal radiation therapy combined with concurrent chemotherapy of cisplatin versus nedaplatin for patients with advanced cervicaI cancer. Method 72 patients with advanced cervical cancer were divided randomly into two groups and treated with a concurrent chemoradiotherapy of cisplatin(30 mg/m2 one time weekly) or nedaplatin(30 mg/m2 one time weekly) with three dimentional conformal radiation therapy. The efficacy and adverse reactions were observed and compared. Results The effective rate of cisplatin and nedapiatin was 91. 7% and 94. 4%,respectively,but the difference between both groups was not significant ( P>0 . 05 ) . The incidence of gastrointestinal toxicity in cisplatin group was higher than that in nedapiatin group(27. 8%,11. 5%,P<0. 05). However,the incidence ofⅢ/Ⅳ myelosuppression in cisplatin group was lower than that in nedapiatin group(19. 4%,30. 5%,P<0. 05). Conclusion The efficacy of combined concurrent chemoradiotherapy of cisplatin or nedaplatin at the same dose is not different significantly and the adverse reactions induced by two treatment regimens are both well-tolerated.关键词
宫颈癌/三维适形放疗/奈达铂/顺铂Key words
cervical cancer/concurrent chemoradiotherapy/cisplatin/nedaplatin分类
医药卫生引用本文复制引用
崔洁,宋丽萍,赵红,胡云峰..周剂量顺铂和奈达铂同步放疗治疗中晚期宫颈癌72例临床分析[J].北华大学学报（自然科学版）,2014,(3):358-361,4.基金项目
陕西省社会发展攻关课题(2012K180504) （2012K180504）
