北华大学学报（自然科学版）Issue(5)：630-632,3.DOI:10.11713/j.issn.1009-4822.2014.05.015
恩替卡韦治疗慢性乙型肝炎肝纤维化的临床观察
Clinical Observation on Hepatic Fibrosis of Chronic Hepatitis B Treated with Entecavir
摘要
Abstract
Objective To evaluate the clinical therapeutic effect of entecavir on hepatic fibrosis serum indicators and liver pathology in chronic hepatitis B. Methods A total of 81 patients with chronic hepatitis B were randomly divided into two groups:41 cases in treatment group were treated with 0. 5mg entecavir,one time per day,40 cases in control group were given the conventional liver drug therapy,and all patients were treated for 48 weeks. After the treatment, the liver fibrosis indicators and liver histopathological changes were observed and compared. Results Levels of serum hepatic fibrosis indicators of the patients in the two groups were both significantly lower, but the decrease of them in treatment group was more significantly compared with that in control group;the liver histopathological changes were significantly improved after the treatment ( P<0 . 05 ) . Conclusion Entecavir has a clear clinical therapeutic effect on hepatic fibrosis of chronic hepatitis B and no obvious adverse reactions.关键词
恩替卡韦/慢性乙型肝炎/肝纤维化Key words
entecavir/chronic hepatitis B/hepatic fibrosis分类
医药卫生引用本文复制引用
郝锐..恩替卡韦治疗慢性乙型肝炎肝纤维化的临床观察[J].北华大学学报（自然科学版）,2014,(5):630-632,3.基金项目
吉林省卫生厅基金项目(20120064) （20120064）
