北华大学学报（自然科学版）Issue(2)：218-221,4.DOI:10.11713/j.issn.1009-4822.2015.02.019
血浆N末端脑利钠肽水平和心脏超声功能参数在评估临床心功能分级中的价值研究
Values of NT-proBNP Level and Cardiac Ultrasound Function Parameters in Evaluating Clinical Heart Function Classification
摘要
Abstract
Objective To investigate the value of NT-proBNP level and cardiac ultrasound function parameters in evaluating clinical heart function classification. Method A total of 106 chronic heart failure ( CHF) patients evaluating were enrolled. Fasting elbow venous blood was collected in the next morning after admission,and the NT-proBNP plasma level was detected by enzyme linked immunosorbent assay. Cardiac function of the patient was graded according to New York Heart Association ( NYHA ) , afterwards, the patient would undergo heart color Doppler ultrasonography. Results Relations between the level of plasma NT-proBNP and heart function classification showed a positive correlation (P<0. 01). The left ventricular shortening fraction,left ventricular ejection fraction and cardiac functional grading were negatively correlated with left ventricular diastolic (P<0. 01). There was a significant positive correlation between end systolic diameter, left ventricular end systolic diameter and heart function classification ( P<0 . 01 ) . The plasma NT-proBNP level and the cardiac ultrasound function parameters between different cardiac function grades had obvious differences ( P<0 . 01 ) . The differences between grade I and II,between III and IV showed no statistical significance (P>0. 05);grade III and grade I,II,grade IV and grade I,II were statistically significant (P<0. 01). The sensitivity and specificity of cardiac function grading diagnosis according to NT-proBNP level combined with cardiac ultrasonography were significantly higher than NT-proBNP level or cardiac ultrasonography (P<0. 05). Conclusion Plasma NT-proBNP level combined with cardiac function parameters of ultrasonic can objectively and accurately judge the heart function of patients with chronic heart failure,which is helpful in guiding clinical treatment and judging prognosis.关键词
慢性心力衰竭/血浆N末端脑利钠肽/超声心动图/心功能分级Key words
hronic heart failure/NT-proBNP/echocardiography/heart function classification分类
医药卫生引用本文复制引用
顾晓薇,陈新颜..血浆N末端脑利钠肽水平和心脏超声功能参数在评估临床心功能分级中的价值研究[J].北华大学学报（自然科学版）,2015,(2):218-221,4.基金项目
无锡市科技局社会发展基金资助项目(CSE01009-01) （CSE01009-01）
