北华大学学报（自然科学版）Issue(4)：458-461,4.DOI:10.11713/j.issn.1009-4822.2015.04.009
阿托伐他汀影响自发性高血压左室肥厚的实验研究
Laboratory Study on the Influence of Atorvastatin on Left Ventricular Hypertrophy in Spontaneously Hypertensive
摘要
Abstract
Objective To study the influence of atorvastatin on the expressions of peroxisome proliferator-activated receptor γ ( PPARγ) and p21 in the hypertrophic myocardium in spontaneously hypertensive rats,and to understand the mechanisms of atorvastatin in improving left ventricular hypertrophy. Method Thirty spontaneously hypertensive rats of 8-week-old within the same batch were randomly divided into blank group, observation group and control group,10 rats in each group. The weight,week-old,male and female ratio were not statistically significant among three groups. The blank group and the healthy control group were given distilled water,and the observation group was administrated 50 mg/( kg · d-1 ) dose of atorvastatin by gavage. Blood pressures of all the rats were measured every five weeks,serum lipid levels and the thicknesses of myocardium were tested after 10 weeks. The immunohistochemistry method and RT-PCR were performed to observe the expression of PPARγ and p21. Results After 10 weeks,the cardiac hypertrophy index of the observation group was significantly lower than that of the control group (P<0. 01),the expressions of PPARγ and p21 in the <br> observation group was significantly higher than those in the control group ( P<0 . 01 ) , and the expressions of PPARγ and p21 mRNA in myocardial tissue showed a negative correlation. Conclusion Atorvastatin can regulate the cell cycle by increasing the expressions of PPARγ and p21 in the hypertrophic myocardium in spontaneously hypertensive rats,and thus improve left ventricular hypertrophy.关键词
阿托伐他汀/自发性高血压大鼠/左室肥厚/过氧化物酶体增殖物激活受体γ/p21Key words
Atorvastatin/spontaneously hypertensive rats/left ventricular hypertrophy/peroxisome proliferator-activated receptor γ/p21分类
医药卫生引用本文复制引用
蒲丽君,赵珂,罗勇..阿托伐他汀影响自发性高血压左室肥厚的实验研究[J].北华大学学报（自然科学版）,2015,(4):458-461,4.基金项目
四川省卫生厅科研基金项目(901911) （901911）
