北京生物医学工程Issue(3)：300-305,6.DOI:10.3969/j.issn.1002-3208.2014.03.14
脑血红蛋白浓度指数在体外循环中的应用
Non-invasive detecting cerebral hemoglobin concentration index used in cardiopulmonary bypass
摘要
Abstract
Objective Using continuous-wave near infrared spectroscopy (NIRS ),human cerebral tissue hemoglobin concentration index (tHI)is detected non-invasively and in real time,so that the change percentage of cerebral total hemoglobin concentration can be indicated and cerebral hemodynamics as well as oxygenation can be evaluated.Methods Based on the propagation of near-infrared light in human brain,the near-infrared oximeter was developed,and the cerebral tHI as well as cerebral oxygen saturation of 8 infants suffered from congenital heart disease were monitored non-invasively and in real time under cardiopulmonary bypass.Results During modified ultrapurification in the end of cardiopulmonary bypass,the cerebral tHI of all the infants increased significantly at the average speed of (0.0304 ±0.01 36)mM/(cm?min),P<0.001 . Comparing the end to the beginning of modified ultrapurification,the cerebral tHI increased for (18.8 ±7.5)%,because the hematocrit was increased by filtering out the redundant water in the blood.The cerebral oxygen <br> saturation increased for (5.3 ±4.1 )% (P <0.05 ), which was not so obvious as the increase trend of cerebral tHI.Conclusions During modified ultrapurification in the end of cardiopulmonary bypass,the changes of cerebral hemodynamics and oxygenation may be indicated effectively by cerebral tHI.关键词
脑/血红蛋白浓度指数/近红外光谱/体外循环/改良超滤Key words
brain/tissue hemoglobin concentration index/near infrared spectroscopy/cardiopulmonary bypass/modified ultrapurification分类
医药卫生引用本文复制引用
贾在申,腾轶超,李岳,谢海秀,刘媛,侯晓彤..脑血红蛋白浓度指数在体外循环中的应用[J].北京生物医学工程,2014,(3):300-305,6.基金项目
教育部高等学校博士点专项科研基金（20090002120014）资助 （）
