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影响骨髓间充质干细胞成骨分化的力学信号传导机制研究进展

刘立跃 王金福

北京生物医学工程Issue(3):294-299,6.
北京生物医学工程Issue(3):294-299,6.DOI:10.3969/j.issn.1002-3208.2015.03.15

影响骨髓间充质干细胞成骨分化的力学信号传导机制研究进展

Advance of mechanism research on osteogenic differentiation of bone marrow stem cells induced by mechanical stimuli

刘立跃 1王金福2

作者信息

  • 1. 宁德师范学院生物系 福建宁德 310025
  • 2. 浙江大学生命科学学院细胞与遗传研究所 杭州310058
  • 折叠

摘要

Abstract

Bone marrow stem cells ( BMSC ) are multipotent adult stem cells with mechanosensitive property.Mechanical stimuli can promote the osteogenic differenitiation of BMSC . In recent years , many studies have been focused on the mechanism for osteogenic differentiation of BMSC although it is not completely clear.It has been reported that several signal pathways are involved in the mechanotransduction of BMSC responding to mechanical stimuli . This review focuses on the advances of recent researches about the mechanism of osteogenic differentiation induced by mechanical stimulation .

关键词

骨髓间充质干细胞/力学刺激/成骨分化/信号通路

Key words

bone marrow stem cell/mechanic stimulus/osteogenic differentiation/signaling pathway

分类

医药卫生

引用本文复制引用

刘立跃,王金福..影响骨髓间充质干细胞成骨分化的力学信号传导机制研究进展[J].北京生物医学工程,2015,(3):294-299,6.

基金项目

福建省教育厅A类科技项目( JA13333)、宁德师范学院服务海西项目(2012H317)资助 ()

北京生物医学工程

OACSTPCD

1002-3208

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