北京大学学报（医学版）Issue(3)：395-399,5.DOI:10.3969/j.issn.1671-167X.2014.03.011
纳米二氧化钛对幼年和成年大鼠肝、肾组织抗氧化功能及元素含量的影响
Effects of TiO2 nanoparticles on antioxidant function and element content of liver and kidney tissues in young and adult rats
摘要
Abstract
Objective:To compare the effect of TiO 2 nanoparticles on antioxidant function and element content of liver and kidney tissues in young and adult rats .Methods:Forty-eight SD male rats , half in 4-week (youth) old and half in 9-week (adult) old rats, were randomly divided into 8 groups, which were exposed to TiO2 nanoparticles [(75 ±15) nm, anatase] through intragastric administration at 0, 10, 50 and 200 mg/kg body weight every day for 30 days.The liver and kidney tissues were collected for antioxidant function and element content analysis .Results: 200 mg/kg TiO2 nanoparticles exposure significantly increased the liver total superoxide dismutase ( T-SOD ) activity and the kidney reduced glutathione (GSH)/oxidized glutathione (GSSG) ratios in young rats, and significantly decreased the liver Mo, Co, Mn and P contents and the kidney Rb and Na contents in young rats .200 mg/kg TiO2 nanoparticles exposure significantly increased GSH/GSSG ratios and Rb contents and decreased Na con-tents in the liver of adult rats .No significantly difference was found in antioxidant indexes and elements content in the kidney of adult rats between three experimental groups and control group .Conclusion:TiO2 nanoparticles can enhance the antioxidant capacity and decrease the elements content in rat liver and kidney tissues .The liver is the more sensitive target organ and the young animals are more susceptible to TiO2 nanoparticles toxicity by the oral routes .关键词
纳米粒子/二氧化钛/安全/肝毒性/肾毒性Key words
Nanoparticles/Titanium dioxide/Safety/Hepatotoxicity/Nephrotoxicity分类
医药卫生引用本文复制引用
王云,陈章健,巴特,濮吉,崔枭醒,贾光..纳米二氧化钛对幼年和成年大鼠肝、肾组织抗氧化功能及元素含量的影响[J].北京大学学报（医学版）,2014,(3):395-399,5.基金项目
国家重点基础研究发展计划（973计划，2011CB933402）、北京市自然科学基金（7132117）和高等学校博士学科点专项科研基金（20110001120027）资助 Supported by the National Basic Research Program of China （973 Program，2011CB933402）， the Beijing Natural Science Foundation （7132117） and the Specialized Research Fund for the Doctoral Program of Higher Education of China （）
